Publications 2019

1. Transfusion Volume for Children with Severe Anemia in Africa. Maitland K, Olupot-Olupot P, Kiguli S, Chagaluka G, Alaroker F, Opoka RO, Mpoya A, Engoru C, Nteziyaremye J, Mallewa M, Kennedy N, Nakuya M, Namayanja C, Kayaga J, Uyoga S, Kyeyune Byabazaire D, M’baya B, Wabwire B, Frost G, Bates I, Evans JA, Williams TN, Saramago Goncalves P, George EC, Gibb DM, Walker AS; TRACT Group.

2. Immediate Transfusion in African Children with Uncomplicated Severe Anemia. Maitland K, Kiguli S, Olupot-Olupot P, Engoru C, Mallewa M, Saramago Goncalves P, Opoka RO, Mpoya A, Alaroker F, Nteziyaremye J, Chagaluka G, Kennedy N, Nabawanuka E, Nakuya M, Namayanja C, Uyoga S, Kyeyune Byabazaire D, M’baya B, Wabwire B, Frost G, Bates I, Evans JA, Williams TN, George EC, Gibb DM, Walker AS; TRACT Group.

3. Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia. Datta D, Namazzi R, Conroy AL, Cusick SE, Hume HA, Tagoola A, Ware RE, Opoka RO, John CC.

4. Biomarkers of Systemic Inflammation in Ugandan Infants and Children Hospitalized With Respiratory Syncytial Virus Infection. Sawatzky J, Soo J, Conroy AL, Bhargava R, Namasopo S, Opoka RO, Hawkes MT.

5. Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study.  Opoka RO, Waiswa A, Harriet N, John CC, Tumwine JK, Karamagi C.

6. Evaluating Immunopathogenic Biomarkers During Severe Malaria Illness as Modifiers of the Neuropsychologic Benefits of Computer Cognitive Games Rehabilitation in Ugandan Children. Boivin MJ, Sikorskii A, Nakasujja N, Ruiseñor-Escudero H, Familiar-Lopez I, Opoka RO, Giordani B.

Publications 2018

1. Ma C, Gunaratnam LC, Ericson A, Conroy AL, Namasopo S, Opoka RO, Hawkes MT: Handheld Point-of-Care Lactate Measurement at Admission Predicts Mortality in Ugandan Children Hospitalized with Pneumonia: A Prospective Cohort Study. The American journal of tropical medicine and hygiene 2018.

2. Ruisenor-Escudero H, Sikorskii A, Familiar-Lopez I, Persaud D, Ziemniak C, Nakasujja N, Opoka R, Boivin M: Neurodevelopmental Outcomes in Pre-School Children Living with HIV-1 Subtypes A and D in Uganda. The Pediatric infectious disease journal 2018, 37 (12):e298-e303.

3. Kwambai TK, Dhabangi A, Idro R, Opoka R, Kariuki S, Samuels AM, Desai M, van Hensbroek MB, John CC, Robberstad B et al: Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial. Trials 2018, 19 (1):610.

4. Escudero H, Familiar I, Nyakato M, Kutessa A, Namukooli J, Ssesanga T, Joyce C, Laughton B, Grab J, Chernoff M et al: Building capacity in neurodevelopment assessment of children in sub-Saharan Africa: A quality assurance model to implement standardized neurodevelopment testing. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence 2018: 1-16.

5. Nakitende AJ, Bangirana P, Nakasujja N, Semrud-Clikeman M, Ssemata AS, John CC, Idro R: “I feel so bad but have nothing to do.” Exploring Ugandan caregivers’ experiences of parenting a child with severe malaria and subsequent repeated uncomplicated malaria. Malaria journal 2018, 17 (1):360.

6. Nallandhighal S, Park GS, Ho YY, Opoka RO, John CC, Tran TM: Whole-blood transcriptional signatures composed of erythropoietic and Nrf2-regulated genes differ between cerebral malaria and severe malarial anemia . The Journal of infectious diseases 2018 .

7. Opoka RO, Ssemata AS, Oyang W, Nambuya H, John CC, Tumwine JK, Karamagi C: High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals. BMC health services research 2018, 18 (1):566.

8. Gladding SP, McGann PT, Summer A, Russ CM, Uwemedimo OT, Matamoros Aguilar M, Chakraborty R, Moore M, Lieh-Lai M, Opoka R et al: The Collaborative Role of North American Departments of Pediatrics in Global Child Health . Pediatrics 2018, 142(1).

9. Hawkes MT, Conroy AL, Namasopo S, Bhargava R, Kain KC, Mian Q, Opoka RO: Solar-Powered Oxygen Delivery in Low-Resource Settings: A Randomized Clinical Noninferiority Trial. JAMA pediatrics 2018, 172 (7):694-696. ).

10. Postels DG, Wu X, Li C, Kaplan PW, Seydel KB, Taylor TE, Kousa YA, Idro R, Opoka R, John CC et al: Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes. Malaria journal 2018, 17(1):208. ).

11. Boivin MJ, Nakasujja N, Sikorskii A, Ruisenor-Escudero H, Familiar-Lopez I, Walhof K, van der Lugt EM, Opoka RO, Giordani B: Neuropsychological Benefits of Computerized Cognitive Rehabilitation Training in Ugandan Children Surviving Severe Malaria: A Randomized Controlled Trial. Brain research bulletin

12. Aramburo A, Todd J, George EC, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G et al: Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa. BMC medicine 2018, 16 (1):37.

13. Finn K, Lori J, Lee M, Giordani B: Interdisciplinary Ugandan perspectives on computerized intervention implementation for child survivors of severe malaria: A qualitative analysis.Applied nursing research : ANR 2018, 39:154-159.

14. Seffren V, Familiar I, Murray SM, Augustinavicius J, Boivin MJ, Nakasujja N, Opoka R, Bass J: Association between coping strategies, social support, and depression and anxiety symptoms among rural Ugandan women living with HIV/AIDSAIDS care 2018:1-8.

15. Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC: Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malariaMalaria journal 2018, 17(1):82

16. Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC. Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trialPLoS One 2018;13:e0191550.

17. Opoka RO, Bangirana P, Idro R, Shabani E, Namazzi R, John CC: Lack of mortality in 22 children with sickle cell anemia and severe malarial anemiaPediatric Blood & Cancer 2018, 65(1).

18. Chhaya, R., Weiss, J., Seffren, V., Sikorskii, A., Winke, P. M., Ojuka, J. C., & Boivin, M. J. (2017). The feasibility of an automated eye-tracking-modified Fagan test of memory for human faces in younger Ugandan HIV-exposed children. Child neuropsychology a journal on normal and abnormal development in childhood and adolescence 2018, 24(5):686-701.

Publications 2017

1. Huang KY, Nakigudde J, Rhule D, Gumikiriza-Onoria JL, Abura G, Kolawole B, Ndyanabangi S, Kim S, Seidman E, Ogedegbe Get alTransportability of an Evidence-Based Early Childhood Intervention in a Low-Income African Country: Results of a Cluster Randomized Controlled StudyPrevention science : the official journal of the Society for Prevention Research 2017, 18(8):964-975.

2. Bangirana P, Ruel TD, Boivin MJ, Pillai SK, Giron LB, Sikorskii A, Banik A, Achan J: Absence of neurocognitive disadvantage associated with paediatric HIV subtype A infection in children on antiretroviral therapyJournal of the International AIDS Society 2017, 20:e25015

3. Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN et alChildren’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumoniaWellcome open research 2017, 2:100.

4. Opoka RO, Ndugwa CM, Latham TS, Lane A, Hume HA, Kasirye P, Hodges JS, Ware RE, John CC: Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemiaBlood 2017, 130:2585-93

5. Boivin MJ, Nakasujja N, Familiar-Lopez I, Murray SM, Sikorskii A, Awadu J, Shohet C, Givon D, Ruisenor-Escudero H, Schut EE et alEffect of Caregiver Training on the Neurodevelopment of HIV-Exposed Uninfected Children and Caregiver Mental Health: A Ugandan Cluster-Randomized Controlled TrialJournal of developmental and behavioral pediatrics 2017, 38:753-64

6. Jaramillo EG, Mupere E, Opoka RO, Hodges JS, Lund TC, Georgieff MK, John CC, Cusick SE: Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiencyPLoS One 2017, 12(8):e0183977.

7. Shabani E, Hanisch B, Opoka RO, Lavstsen T, John CC: Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malariaBMC medicine 2017, 15(1):183.

8. Park GS, Opoka RO, Shabani E, Wypyszynski A, Hanisch B, John CC: Plasmodium falciparum histidine-rich protein-2 plasma concentrations are higher in retinopathy-negative cerebral malaria than in severe malarial anemia. In: Open Forum Infectious Diseases: 2017, 4(3):ofx151-ofx151.

9. Semrud-Clikeman M, Romero RAA, Prado EL, Shapiro EG, Bangirana P, John CC: Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countriesChild Neuropsychology 2017, 23(7):761-802.

10. Tumukunde VS, Kiboneka E, John CC, Opoka RO, Idro R:

11. Holmberg D, Franzén-Röhl E, Idro R, Opoka RO, Bangirana P, Sellgren CM, Wickström R, Färnert A, Schwieler L, Engberg G et alCerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malariaMalaria journal 2017, 16(1):303.

12. Ssemata AS, Gladding S, John CC, Kiguli S: Developing mentorship in a resource-limited context: a qualitative research study of the experiences and perceptions of the makerere university student and faculty mentorship programmeBMC medical education 2017, 17(1):123.

13. Opoka RO, Hamre KES, Brand N, Bangirana P, Idro R, John CC: High Postdischarge Morbidity in Ugandan Children With Severe Malarial Anemia or Cerebral MalariaJournal of the Pediatric Infectious Diseases Society 2017, 6(3):e41-e48.

14. Boivin, M. J., Weiss, J., Chhaya, R., Seffren, V., Awadu, J., Sikorskii, A., & Giordani, B. (2017). The feasibility of automated eye tracking with the Early Childhood Vigilance Test of attention in younger HIV-exposed Ugandan childrenNeuropsychology, 31(5), 525-534. doi: 10.1037/neu0000382

15. Huang KY, Abura G, Theise R, Nakigudde J: Parental Depression and Associations with Parenting and Children’s Physical and Mental Health in a Sub-Saharan African Setting. .Child psychiatry and human development 2017, 48(4):517-527.

16. Bass JK, Opoka R, Familiar I, Nakasujja N, Sikorskii A, Awadu J, Givon D, Shohet C, Murray SM, Augustinavicius J et al: Randomized controlled trial of caregiver training for HIV-infected child neurodevelopment and caregiver well-being. AIDS (London, England) 2017, 31(13):1877-1883.

17. Chhaya, R., Weiss, J., Seffren, V., Sikorskii, A., Winke, P. M., Ojuka, J. C., & Boivin, M. J. (2017). The feasibility of an automated eye-tracking-modified Fagan test of memory for human faces in younger Ugandan HIV-exposed children. Child Neuropsychol, 1-16. doi: 10.1080/09297049.2017.1329412

18. Huang KY, Abura G, Theise R, Nakigudde J: Parental Depression and Associations with Parenting and Children’s Physical and Mental Health in a Sub-Saharan African SettingChild psychiatry and human development 2017, 48(4):517-527.

19. Shabani E, Ouma BJ, Idro R, Bangirana P, Opoka RO, Park GS, Conroy AL, John CC: Elevated cerebrospinal fluid tumor necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malariaParasite Immunology 2017, 39(7).

20. Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R et alHigh Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern UgandaClinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64(7):939-946.

21. Villaverde C, Namazzi R, Shabani E, Opoka RO, John CC: Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral MalariaThe American journal of tropical medicine and hygiene 2017, 96(5):1176-1184..

22. Murray SM, Familiar I, Nakasujja N, Winch PJ, Gallo JJ, Opoka R, Caesar JO, Boivin MJ, Bass JK: Caregiver mental health and HIV-infected child wellness: perspectives from Ugandan caregivers. AIDS care 2017, 29(6):793-799.

23. Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R et alHigh Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern UgandaClinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64(7):939-946.

24. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC: Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infectionPLoS One 2017, 12(4):e0175130.

25. Huang K-Y, Abura G, Theise R, Nakigudde J: Parental Depression and Associations with Parenting and Children’s Physical and Mental Health in a Sub-Saharan African SettingChild psychiatry and human development 2017, 48(4):517-527

26. McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC: Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe MalariaThe Pediatric infectious disease journal 2017, 36(2):146-150.

27. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: B-type natriuretic peptide and plasma hemoglobin levels following transfusion of shorter-storage versus longer-storage red blood cells: Results from the TOTAL randomized trialAmerican heart journal 2017, 183:129-136.

Publications 2016

1. Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC et alMethemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trialBMC Pediatrics 2016, 16(1):177.

2. Opoka RO, Hamre KES, Brand N, Bangirana P, Idro R, John CC: High Postdischarge Morbidity in Ugandan Children With Severe Malarial Anemia or Cerebral MalariaJournal of the Pediatric Infectious Diseases Society 2017, 6(3):e41-e48.

3. Brand NR, Opoka RO, Hamre KE, John CC: Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related MortalityPLOS ONE 2016, 11(9):e0163728.

4. Ssenkusu JM, Hodges JS, Opoka RO, Idro R, Shapiro E, John CC, Bangirana P: Long-term Behavioral Problems in Children With Severe Malaria. Pediatrics 2016: Nov;138(5).

5. Familiar I, Murray S, Ruisenor-Escudero H, Sikorskii A, Nakasujja N, Boivin MJ, Opoka R, Bass JK: Socio-demographic correlates of depression and anxiety among female caregivers living with HIV in rural UgandaAIDS Care 2016, 28(12):1541-1545.

6. Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC: Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe MalariaJ Infect Dis 2016, 214(8):1268-1275

7. Cusick SE, John CC: Iron, Inflammation, and Malaria in the Pregnant Woman and Her Child: Saving Lives, Saving BrainsAm J Trop Med Hyg 2016, 95(4):739-740.

8. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: Cerebral Oximetry in Ugandan Children With Severe Anemia: Clinical Categories and Response to Transfusion. JAMA Pediatr 2016, 170(10):995-1002.

9. Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE et alDysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malariaScience translational medicine 2016, 8(358):358ra128.

10. Huang K-Y, Abura G, Theise R, Nakigudde J: Parental Depression and Associations with Parenting and Children’s Physical and Mental Health in a Sub-Saharan African SettingChild Psychiatry & Human Development 2016:1-11.

11. Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC et alHost Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe MalariaOpen forum infectious diseases 2016, 3(3):ofw134.

12. Cusick SE, Opoka RO, Abrams SA, John CC, Georgieff MK, Mupere E: Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial. J Nutr 2016, 146(9):1769-1774.

13. Anyanwu JN, Williams O, Sautter CL, Kasirye P, Hume H, Opoka RO, Latham T, Ndugwa C, Ware RE, John CC: Novel Use of Hydroxyurea in an African Region With Malaria: Protocol for a Randomized Controlled Clinical TrialJMIR research protocols 2016, 5(2):e110

14. Shabani E, Opoka RO, Bangirana P, Park GS, Vercellotti GM, Guan W, Hodges JS, Lavstsen T, John CC: The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malariaScientific Reports 2016, 6:27084.

15. Idro R, Kakooza-Mwesige A, Asea B, Ssebyala K, Bangirana P, Opoka RO, Lubowa SK, Semrud-Clikeman M, John CC, Nalugya J: Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohortMalaria Journal 2016, 15(1):1-11.

16. Boivin MJ, Nakasujja N, Sikorskii A, Opoka RO, Giordani B: A Randomized Controlled Trial to Evaluate if Computerized Cognitive Rehabilitation Improves Neurocognition in Ugandan Children with HIVAIDS Research and Human Retroviruses 2016, 32(8):743-755.

17. Boivin MJ, Sikorskii A, Familiar-Lopez I, Ruiseñor-Escudero H, Muhindo M, Kapisi J, Bigira V, Bass JK, Opoka RO, Nakasujja N: Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan childrenMalaria Journal 2016, 15(1):1.

18. Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC: Acute kidney injury is common in pediatric severe malaria and is associated with increased risk of acute and long-term mortality: a prospective cohort study. In: Open Forum Infectious Diseases: 2016, 3(2):ofw046-ofw046

19. Turnbull H, Conroy A, Opoka RO, Namasopo S, Kain KC, Hawkes M: Solar-powered oxygen delivery: proof of concept. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016, 20(5):696-703.

20. Bass JK, Nakasujja N, Familiar-Lopez I, Sikorskii A, Murray SM, Opoka R, Augustinavicius J, Boivin MJ: Association of caregiver quality of care with neurocognitive outcomes in HIV-affected children aged 2-5 years in Uganda. AIDS Care 2016:1-8.

21. Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, Lopez JA, Liles WC: Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trialMalaria journal 2016, 15:56

22. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, John CC: Neurocognitive domains affected by cerebral malaria and severe malarial anemia in childrenLearning and Individual Differences 2016, 46:38-44.

23. Familiar I, Nakasujja N, Bass J, Sikorskii A, Murray SM, Ruisenor-Escudero H, Bangirana P, Opoka R, Boivin MJ: Caregivers’ depressive symptoms and parent-report of child executive function among young children in Uganda. Learn Individ Differ 2016, 46:17-24

Publications 2015

1. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical TrialJAMA 2015, 314(23):2514-2523.

2. Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B et alTransfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trialTrials 2015, 16(1):593.

3. John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK: Global research priorities for infections that affect the nervous systemNature 2015, 527(7578):S178-S186.

4. Hawkes MT, Conroy AL, Opoka RO, Hermann L, Thorpe KE, McDonald C, Kim H, Higgins S, Namasopo S, John C et alInhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trialMalaria journal 2015, 14(1):421.

5. Bangirana P, Sikorskii A, Giordani B, Nakasujja N, Boivin MJ: Validation of the CogState battery for rapid neurocognitive assessment in Ugandan school age childrenChild and adolescent psychiatry and mental health 2015, 9(1):1-7.

6. Ruiseñor-Escudero H, Familiar I, Nakasujja N, Bangirana P, Opoka R, Giordani B, Boivin M: Immunological correlates of behavioral problems in school-aged children living with HIV in Kayunga, UgandaGlobal Mental Health 2015, 2

7. George EC, Walker AS, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) ScoreBMC medicine 201513:174.

8. Nyende S, Conroy A, Opoka RO, Namasopo S, Kain KC, Mpimbaza A, Bhargava R, Hawkes M: Solar-powered oxygen delivery: study protocol for a randomized controlled trialTrials 2015, 16(1):297

9. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Zhong K, Liles WC, John CC, Kain KC: Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013Emerging infectious diseases 2015, 21(7):1237-1239.

10. Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC: Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illnessCritical care (London, England) 2015, 19:47.

11. Hanisch BR, Bangirana P, Opoka RO, Park GS, John CC: Thrombocytopenia May Mediate Disease Severity in Plasmodium falciparum Malaria Through Reduced Transforming Growth Factor Beta-1 Regulation of Proinflammatory and Anti-inflammatory CytokinesPediatr Infect Dis J 2015, 34(7):783-788.

12. Familiar I, Ruisenor-Escudero H, Giordani B, Bangirana P, Nakasujja N, Opoka RO, Boivin MJ: Use of BRIEF and CBCL in Ugandan children with HIV or history of severe malaria. J Dev Behav Pediatr 2015, 36(4):277-284.

13. Burkey MD, Murray SM, Bangirana P, Familiar I, Opoka RO, Nakasujja N, Boivin MJ, Bass J: Executive function and attention-deficit/hyperactivity disorder in Ugandan children with perinatal HIV exposureGlobal Mental Health 2015, 2:e4.

14. Shabani E, Vercellotti GM, John CC: Reply to Eisenhut. Clin Infect Dis 2015, 60(7):1138-1139.

15. Familiar I, Nakasujja N, Bass J, Sikorskii A, Murray SM, Ruisenor-Escudero H, Bangirana P, Opoka R, Boivin MJ: Caregivers’ depressive symptoms and parent-report of child executive function among young children in UgandaLearning and Individual Differences 2015(0).

16. Shabani E, Vercellotti GM, John CC: Reply to EisenhutClin Infect Dis 2015, 60(7):1138-1139.

17. Shabani E, Opoka RO, Idro R, Schmidt R, Park GS, Bangirana P, Vercellotti GM, Hodges JS, Widness JA, John CC: High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malariaClin Infect Dis 2015, 60(1):27-35.

18. Kiguli S, Maitland K, George EC, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness. BMC medicine 2015, 13:21.

19. Bangirana P: Cognitive outcome of malaria and HIV infection in children in sub-Saharan Africa. In: Brain Degeneration and Dementia in Sub-Saharan Africa. Edited by Musisi S, Jacobson S. New York: Springer; 2015.

Publications 2014

1. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC: Performance of point-of-care diagnostics for glucose, lactate, and hemoglobin in the management of severe malaria in a resource-constrained hospital in UgandaAm J Trop Med Hyg 2014, 90(4):605-608.

2. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC: Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan childrenMalar J 2014, 13:43.

3. Cusick SE, Opoka RO, Lund TC, John CC, Polgreen LE: Vitamin D insufficiency is common in Ugandan children and is associated with severe malariaPLoS One 2014, 9(12):e113185.

4. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, Romero RA, Shapiro E, John CC: Severe malarial anemia is associated with long-term neurocognitive impairmentClinical Infectious Diseases 2014:doi: 10.1093/cid/ciu1293-doi: 1010.1093/cid/ciu1293.

5. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: Authors’ reply to SouthallBMJ (Clinical research ed) 2014, 348:g1619.

6. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: WHO guidelines on fluid resuscitation in children: missing the FEAST data. BMJ (Clinical research ed) 2014, 348:f7003.

Publications 2013

1. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, Bass JK, Opoka RO, Klein PS: A year-long caregiver training program to improve neurocognition in preschool Ugandan HIV-exposed children. J Dev Behav Pediatr 2013, 34(4):269-278.

2. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, Bass JK, Opoka RO, Klein PS: A year-long caregiver training program improves cognition in preschool Ugandan children with human immunodeficiency virusThe Journal of pediatrics 2013, 163(5):1409-1416 e1401-1405.

3. Bangirana P, Menk J, John CC, Boivin MJ, Hodges JS: The Association between Cognition and Academic Performance in Ugandan Children Surviving Malaria with Neurological InvolvementPLoS ONE 2013, 8(2):e55653-e55653.

4. Bangirana P, Boivin MJ, Giordani B: Computerized Cognitive Rehabilitation Therapy (CCRT) for African Children: Evidence for Neuropsychological Benefit and Future Directions. In: Neuropsychology of Children in Africa. Edited by Boivin MJ, Giordani B: Springer New York; 2013: 277-297.

5. Maitland K, George EC, Evans JA, Kiguli S, Olupot-Olupot P, Akech SO, Opoka RO, Engoru C, Nyeko R, Mtove G et al: Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC medicine 2013,11 :68.

Publications 2012

1. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C et alNeurocognitive and Motor Deficits in HIV-Infected Ugandan Children With High CD4 Cell CountsClin Infect Dis 2012, 54(7):1001-1009.

2. Park GS, Ireland KF, Opoka RO, John CC: Evidence of Endothelial Activation in Asymptomatic Parasitemia and Effect of Blood Group on Levels of von Willebrand Factor in MalariaJournal of the Pediatric Infectious Diseases Society 2012, 1(1):16-25.

3. Greene JA, Sam-Agudu N, John CC, Opoka RO, Zimmerman PA, Kazura JW: Toll-like receptor polymorphisms and cerebral malaria: TLR2 Delta22 polymorphism is associated with protection from cerebral malaria in a case control studyMalar J 2012, 11:47.

4. Bergemann TL, Bangirana P, Boivin MJ, Connett JE, Giordani BJ, John CC: Statistical Approaches to Assess the Effects of Disease on Neurocognitive Function Over TimeJournal of biometrics & biostatistics 2012, Suppl 7.

Publications 2011

1. Hawkes M, Opoka RO, Namasopo S, Miller C, Thorpe KE, Lavery JV, Conroy AL, Liles WC, John CC, Kain KC: Inhaled nitric oxide for the adjunctive therapy of severe malaria: Protocol for a randomized controlled trialTrials 2011, 12:176.

2. Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H, Thampi N, Liles WC, John CC et alNitric oxide for the adjunctive treatment of severe malaria: Hypothesis and rationaleMed Hypotheses

3. Bangirana P, Musisi S, Boivin MJ, Ehnvall A, John CC, Bergemann TL, Allebeck P: Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviourMalar J 2011, 10:334.

4. Bangirana P, Allebeck P, Boivin MJ, John CC, Page C, Ehnvall A, Musisi S: Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trialBMC Neurology 2011, 11(1):96

Publications 2010

1. Sam-Agudu NA, Greene JA, Opoka RO, Kazura JW, Boivin MJ, Zimmerman PA, Riedesel MA, Bergemann TL, Schimmenti LA, John CC: TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malariaAm J Trop Med Hyg 2010, 82(4):548-555.

2. Robertson K, Liner J, Hakim J, Sankale J-L, Grant I, Letendre S, Clifford D, Diop AG, Jaye A, Kanmogne G et alNeuroAIDS in AfricaJournal of Neurovirology 2010, 16(3):189-202.

3. John CC, Kutamba E, Mugarura K, Opoka RO: Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malariaExpert Rev Anti Infect Ther 2010, 8(9):997-1008.

4. Boivin MJ, Ruel TD, Boal HE, Bangirana P, Cao H, Eller LA, Charlebois E, Havlir DV, Kamya MR, Achan J et alHIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan childrenAIDS 2010, 24(8):1163-1170 1110.1097/QAD.1160b1013e3283389dcc

5. Boivin MJ, Busman RA, Parikh SM, Bangirana P, Page CF, Opoka RO, Giordani B: A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIVNeuropsychology 2010, 24(5):667-673.

6. Boivin MJ, Bangirana P, Shaffer RC: The Relationship between Visual-Spatial and Auditory-Verbal Working Memory Span in Senegalese and Ugandan ChildrenPLoS One 2010, 5(1):e8914.

Publications 2009

1. Lovegrove FE, Tangpukdee N, Opoka RO, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC et alSerum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African childrenPLoS One 2009, 4(3):e4912.

2. Bangirana P, Nakasujja N, Giordani B, Opoka RO, John CC, Boivin MJ: Reliability of the Luganda version of the Child Behaviour Checklist in measuring behavioural problems after cerebral malariaChild Adolesc Psychiatry Ment Health 2009, 3:38.

3. Bangirana P, Musisi S, Allebeck P, Giordani B, John CC, Opoka RO, Byarugaba J, Ehnvall A, Boivin MJ: A preliminary investigation of the construct validity of the KABC-II in Ugandan children with prior cerebral insult. African Health Sciences 2009, 9(3):186-192.

4. Bangirana P, John CC, Idro R, Opoka RO, Byarugaba J, Jurek AM, Boivin MJ: Socioeconomic predictors of cognition in Ugandan children: implications for community interventionsPLoS One 2009, 4(11):e7898.

5. Bangirana P, Giordani B, John CC, Page C, Opoka RO, Boivin MJ: Immediate Neuropsychological and Behavioral Benefits of Computerized Cognitive Rehabilitation in Ugandan Pediatric Cerebral Malaria SurvivorsJ Dev Behav Pediatr 2009, 30(4):310-318.

Publications 2008

1. Opoka RO, Xia Z, Bangirana P, John CC: Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malariaPediatr Infect Dis J 2008, 27(4):319-324.

2. John CC, Park GS, Sam-Agudu N, Opoka RO, Boivin MJ: Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of diseaseCytokine 2008, 41(3):204-208.

3. John CC, Panoskaltsis-Mortari A, Opoka RO, Park GS, Orchard PJ, Jurek AM, Idro R, Byarugaba J, Boivin MJ: Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malariaAm J Trop Med Hyg 2008, 78(2):198-205.

4. John CC, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, Wu B, Boivin MJ: Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics 2008, 122(1):e92-99.

Publications 2007

1. Boivin MJ, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, John CC: Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics 2007, 119(2):e360-366.

Publications 2006

1. John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin MJ: Low levels of RANTES are associated with mortality in children with cerebral malariaJ Infect Dis 2006, 194(6):837-845.

2. Bangirana P, Idro R, John CC, Boivin MJRehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitationsTrop Med Int Health 2006, 11(9):1341-1349.