A Multi - Disciplinary Research Collaboration.

publications

1. Ssenkusu JM, Hodges JS, Opoka RO, Idro R, Shapiro E, John CC, Bangirana P: Long-term Behavioral Problems in Children With Severe Malaria. Pediatrics 2016.

2. Familiar I, Murray S, Ruisenor-Escudero H, Sikorskii A, Nakasujja N, Boivin MJ, Opoka R, Bass JK: Socio-demographic correlates of depression and anxiety among female caregivers living with HIV in rural Uganda. AIDS Care 2016, 28(12):1541-1545.

3. Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC: Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria. J Infect Dis 2016, 214(8):1268-1275

4. Cusick SE, John CC: Iron, Inflammation, and Malaria in the Pregnant Woman and Her Child: Saving Lives, Saving Brains. Am J Trop Med Hyg 2016, 95(4):739-740.

5. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: Cerebral Oximetry in Ugandan Children With Severe Anemia: Clinical Categories and Response to Transfusion. JAMA Pediatr 2016, 170(10):995-1002.

6. Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE et al: Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria. Science translational medicine 2016, 8(358):358ra128.

7. Semrud-Clikeman M, Romero RA, Prado EL, Shapiro EG, Bangirana P, John CC: Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries. Child Neuropsychol 2016:1-42.

8. Huang K-Y, Abura G, Theise R, Nakigudde J: Parental Depression and Associations with Parenting and Children’s Physical and Mental Health in a Sub-Saharan African Setting. Child Psychiatry & Human Development 2016:1-11.

9. Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC et al: Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria. Open forum infectious diseases 2016, 3(3):ofw134.

10. Cusick SE, Opoka RO, Abrams SA, John CC, Georgieff MK, Mupere E: Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial. The Journal of Nutrition 2016.2.

11. Anyanwu JN, Williams O, Sautter CL, Kasirye P, Hume H, Opoka RO, Latham T, Ndugwa C, Ware RE, John CC: Novel Use of Hydroxyurea in an African Region With Malaria: Protocol for a Randomized Controlled Clinical Trial. JMIR research protocols 2016, 5(2):e110

12. Shabani E, Opoka RO, Bangirana P, Park GS, Vercellotti GM, Guan W, Hodges JS, Lavstsen T, John CC: The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria. Scientific Reports 2016, 6:27084.

13. Familiar I, Murray S, Ruisenor-Escudero H, Sikorskii A, Nakasujja N, Boivin MJ, Opoka R, Bass JK: Socio-demographic correlates of depression and anxiety among female caregivers living with HIV in rural Uganda. AIDS Care 2016:1-5.

14. Idro R, Kakooza-Mwesige A, Asea B, Ssebyala K, Bangirana P, Opoka RO, Lubowa SK, Semrud-Clikeman M, John CC, Nalugya J: Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort. Malaria Journal 2016, 15(1):1-11.

15. Boivin MJ, Nakasujja N, Sikorskii A, Opoka RO, Giordani B: A Randomized Controlled Trial to Evaluate if Computerized Cognitive Rehabilitation Improves Neurocognition in Ugandan Children with HIV. AIDS Research and Human Retroviruses 2016(ja)

16. Boivin MJ, Sikorskii A, Familiar-Lopez I, Ruiseñor-Escudero H, Muhindo M, Kapisi J, Bigira V, Bass JK, Opoka RO, Nakasujja N: Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan children. Malaria Journal 2016, 15(1):1.

17. Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC: Acute kidney injury is common in pediatric severe malaria and is associated with increased risk of acute and long-term mortality: a prospective cohort study. In: Open Forum Infectious Diseases: 2016: Oxford.

18. Turnbull H, Conroy A, Opoka RO, Namasopo S, Kain KC, Hawkes M: Solar-powered oxygen delivery: proof of concept. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016, 20(5):696-703.

19.Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: B-type natriuretic peptide and plasma hemoglobin levels following transfusion of shorter-storage versus longer-storage red blood cells: Results from the TOTAL randomized trial. American Heart Journal. In press

20. Bass JK, Nakasujja N, Familiar-Lopez I, Sikorskii A, Murray SM, Opoka R, Augustinavicius J, Boivin MJ: Association of caregiver quality of care with neurocognitive outcomes in HIV-affected children aged 2-5 years in Uganda. AIDS Care 2016:1-8..

21. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical Trial. JAMA 2015, 314(23):2514-2523.

22. Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B et al: Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial. Trials 2015, 16(1):593.

23. John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK: Global research priorities for infections that affect the nervous system. Nature 2015, 527(7578):S178-S186.

24. Bangirana P, Sikorskii A, Giordani B, Nakasujja N, Boivin MJ: Validation of the CogState battery for rapid neurocognitive assessment in Ugandan school age children. Child and adolescent psychiatry and mental health 2015, 9(1):1-7.

25. Ruiseñor-Escudero H, Familiar I, Nakasujja N, Bangirana P, Opoka R, Giordani B, Boivin M: Immunological correlates of behavioral problems in school-aged children living with HIV in Kayunga, Uganda. Global Mental Health 2015, 2

26. Nyende S, Conroy A, Opoka RO, Namasopo S, Kain KC, Mpimbaza A, Bhargava R, Hawkes M: Solar-powered oxygen delivery: study protocol for a randomized controlled trial. Trials 2015, 16(1):297.

27. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Zhong K, Liles WC, John CC, Kain KC: Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013. Emerging infectious diseases 2015, 21(7):1237-1239.

28. Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC: Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness. Critical care (London, England) 2015, 19:47

29. Hanisch BR, Bangirana P, Opoka RO, Park GS, John CC: Thrombocytopenia May Mediate Disease Severity in Plasmodium falciparum Malaria Through Reduced Transforming Growth Factor Beta-1 Regulation of Proinflammatory and Anti-inflammatory Cytokines. Pediatr Infect Dis J 2015, 34(7):783-788.

30. Familiar I, Ruisenor-Escudero H, Giordani B, Bangirana P, Nakasujja N, Opoka RO, Boivin MJ: Use of BRIEF and CBCL in Ugandan children with HIV or history of severe malaria. J Dev Behav Pediatr 2015, 36(4):277-284.

31. Burkey MD, Murray SM, Bangirana P, Familiar I, Opoka RO, Nakasujja N, Boivin MJ, Bass J: Executive function and attention-deficit/hyperactivity disorder in Ugandan children with perinatal HIV exposure. Global Mental Health 2015, 2:e4.

32. Familiar I, Nakasujja N, Bass J, Sikorskii A, Murray SM, Ruisenor-Escudero H, Bangirana P, Opoka R, Boivin MJ: Caregivers’ depressive symptoms and parent-report of child executive function among young children in Uganda. Learning and Individual Differences 2015(0).

33. Shabani E, Vercellotti GM, John CC: Reply to Eisenhut. Clin Infect Dis 2015, 60(7):1138-1139.

34. Shabani E, Opoka RO, Idro R, Schmidt R, Park GS, Bangirana P, Vercellotti GM, Hodges JS, Widness JA, John CC: High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria. Clin Infect Dis 2015, 60(1):27-35.

35. Bangirana P: Cognitive outcome of malaria and HIV infection in children in sub-Saharan Africa. In: Brain Degeneration and Dementia in Sub-Saharan Africa. Edited by Musisi S, Jacobson S. New York: Springer; 2015.

36. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, John CC: Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children. Learning and Individual Differences 2015(0).

37. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC: Performance of point-of-care diagnostics for glucose, lactate, and hemoglobin in the management of severe malaria in a resource-constrained hospital in Uganda. Am J Trop Med Hyg 2014, 90(4):605-608.

38. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC: Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children. Malar J 2014, 13:43.

39. Cusick SE, Opoka RO, Lund TC, John CC, Polgreen LE: Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. PLoS One 2014, 9(12):e113185.

40. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, Romero RA, Shapiro E, John CC: Severe malarial anemia is associated with long-term neurocognitive impairment. Clinical Infectious Diseases 2014:doi: 10.1093/cid/ciu1293-doi: 1010.1093/cid/ciu1293.

41. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, Bass JK, Opoka RO, Klein PS: A year-long caregiver training program to improve neurocognition in preschool Ugandan HIV-exposed children. J Dev Behav Pediatr 2013, 34(4):269-278.

42. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, Bass JK, Opoka RO, Klein PS: A year-long caregiver training program improves cognition in preschool Ugandan children with human immunodeficiency virus. The Journal of pediatrics 2013, 163(5):1409-1416 e1401-1405.

43. Bangirana P, Menk J, John CC, Boivin MJ, Hodges JS: The Association between Cognition and Academic Performance in Ugandan Children Surviving Malaria with Neurological Involvement. PLoS ONE 2013, 8(2):e55653-e55653.

44. Bangirana P, Boivin MJ, Giordani B: Computerized Cognitive Rehabilitation Therapy (CCRT) for African Children: Evidence for Neuropsychological Benefit and Future Directions. In: Neuropsychology of Children in Africa. Edited by Boivin MJ, Giordani B: Springer New York; 2013: 277-297

45. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C et al: Neurocognitive and Motor Deficits in HIV-Infected Ugandan Children With High CD4 Cell Counts. Clin Infect Dis

46. Park GS, Ireland KF, Opoka RO, John CC: Evidence of Endothelial Activation in Asymptomatic Parasitemia and Effect of Blood Group on Levels of von Willebrand Factor in Malaria. Journal of the Pediatric Infectious Diseases Society 2012, 1(1):16-25.

47. Greene JA, Sam-Agudu N, John CC, Opoka RO, Zimmerman PA, Kazura JW: Toll-like receptor polymorphisms and cerebral malaria: TLR2 Delta22 polymorphism is associated with protection from cerebral malaria in a case control study. Malar J 2012, 11:47.

48. Bergemann TL, Bangirana P, Boivin MJ, Connett JE, Giordani BJ, John CC: Statistical Approaches to Assess the Effects of Disease on Neurocognitive Function Over Time. Journal of biometrics & biostatistics 2012, Suppl 7

49. Hawkes M, Opoka RO, Namasopo S, Miller C, Thorpe KE, Lavery JV, Conroy AL, Liles WC, John CC, Kain KC: Inhaled nitric oxide for the adjunctive therapy of severe malaria: Protocol for a randomized controlled trial. Trials 2011, 12:176.

50. Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H, Thampi N, Liles WC, John CC et al: Nitric oxide for the adjunctive treatment of severe malaria: Hypothesis and rationale. Med Hypotheses 2011.

51. Bangirana P, Musisi S, Boivin MJ, Ehnvall A, John CC, Bergemann TL, Allebeck P: Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviour. Malar J 2011, 10:334.

52. Bangirana P, Allebeck P, Boivin MJ, John CC, Page C, Ehnvall A, Musisi S: Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial. BMC Neurology 2011, 11(1):96.

53. Sam-Agudu NA, Greene JA, Opoka RO, Kazura JW, Boivin MJ, Zimmerman PA, Riedesel MA, Bergemann TL, Schimmenti LA, John CC: TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. Am J Trop Med Hyg 2010, 82(4):548-555.

54. Robertson K, Liner J, Hakim J, Sankale J-L, Grant I, Letendre S, Clifford D, Diop AG, Jaye A, Kanmogne G et al: NeuroAIDS in Africa. Journal of Neurovirology 2010, 16(3):189-202.

55. John CC, Kutamba E, Mugarura K, Opoka RO: Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria. Expert Rev Anti Infect Ther 2010, 8(9):997-1008.

56. Boivin MJ, Ruel TD, Boal HE, Bangirana P, Cao H, Eller LA, Charlebois E, Havlir DV, Kamya MR, Achan J et al: HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children. AIDS 2010, 24(8):1163-1170 1110.1097/QAD.1160b1013e3283389dcc

57. Boivin MJ, Busman RA, Parikh SM, Bangirana P, Page CF, Opoka RO, Giordani B: A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV. Neuropsychology 2010, 24(5):667-673.

58. Boivin MJ, Bangirana P, Shaffer RC: The Relationship between Visual-Spatial and Auditory-Verbal Working Memory Span in Senegalese and Ugandan Children. PLoS One 2010, 5(1):e8914.

59. Lovegrove FE, Tangpukdee N, Opoka RO, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC et al: Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One 2009, 4(3):e4912.

60. Bangirana P, Nakasujja N, Giordani B, Opoka RO, John CC, Boivin MJ: Reliability of the Luganda version of the Child Behaviour Checklist in measuring behavioural problems after cerebral malaria. Child Adolesc Psychiatry Ment Health 2009, 3:38.

61. Bangirana P, Musisi S, Allebeck P, Giordani B, John CC, Opoka RO, Byarugaba J, Ehnvall A, Boivin MJ: A preliminary investigation of the construct validity of the KABC-II in Ugandan children with prior cerebral insult. African Health Sciences 2009, 9(3):186-192.

61. Bangirana P, John CC, Idro R, Opoka RO, Byarugaba J, Jurek AM, Boivin MJ: Socioeconomic predictors of cognition in Ugandan children: implications for community interventions. PLoS One 2009, 4(11):e7898.

62. Bangirana P, Giordani B, John CC, Page C, Opoka RO, Boivin MJ: Immediate Neuropsychological and Behavioral Benefits of Computerized Cognitive Rehabilitation in Ugandan Pediatric Cerebral Malaria Survivors. J Dev Behav Pediatr 2009, 30(4):310-318.

63. Opoka RO, Xia Z, Bangirana P, John CC: Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria. Pediatr Infect Dis J 2008, 27(4):319-324.

64. John CC, Park GS, Sam-Agudu N, Opoka RO, Boivin MJ: Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease. Cytokine 2008, 41(3):204-208.

65. John CC, Panoskaltsis-Mortari A, Opoka RO, Park GS, Orchard PJ, Jurek AM, Idro R, Byarugaba J, Boivin MJ: Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria. Am J Trop Med Hyg 2008, 78(2):198-205.

66. John CC, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, Wu B, Boivin MJ: Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics 2008, 122(1):e92-99.

67. Boivin MJ, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, John CC: Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics 2007, 119(2):e360-366.

68. John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin MJ: Low levels of RANTES are associated with mortality in children with cerebral malaria. J Infect Dis 2006, 194(6):837-845.

69. Bangirana P, Idro R, John CC, Boivin MJ: Rehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitations. Trop Med Int Health 2006, 11(9):1341-1349.

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