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GLOBAL HEALTH UGANDA

A Multi-Disciplinary Research Collaboration

GLOBAL HEALTH UGANDA

A Multi-Disciplinary Research Collaboration

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All GHU Publications

Publications 2023

  1. Namazzi, R., Opoka, R., Conroy, A. L., Datta, D., Tagoola, A., Bond, C., Goings, M. J., Ryu, M. S., Cusick, S. E., Krebs, N. F., Jang, J. H., Tu, W., Ware, R. E., & John, C. C. (2023). Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial. Blood Adv, 7(13), 3023-3031. https://doi.org/10.1182/bloodadvances.2022008539
  2. Teigen, D., Opoka, R. O., Kasirye, P., Nabaggala, C., Hume, H. A., Blomberg, B., John, C. C., Ware, R. E., & Robberstad, B. (2023). Cost-Effectiveness of Hydroxyurea for Sickle Cell Anemia in a Low-Income African Setting: A Model-Based Evaluation of Two Dosing Regimens. Pharmacoeconomics. https://doi.org/10.1007/s40273-023-01294-3
  3. Conroy, A. L., Datta, D., Opoka, R. O., Batte, A., Bangirana, P., Gopinadhan, A., Mellencamp, K. A., Akcan-Arikan, A., Idro, R., & John, C. C. (2023). Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis. Front Hum Neurosci, 17, 1177242. https://doi.org/10.3389/fnhum.2023.1177242
  4. Nakitende, A. J., Bangirana, P., Nakasujja, N., Ssenkusu, J. M., Bond, C., Idro, R., Zhao, Y., Semrud-Clikeman, M., & John, C. C. (2023). Severe Malaria and Academic Achievement. Pediatrics, 151(4). https://doi.org/10.1542/peds.2022-058310
  5. Mitran, C., Opoka, R. O., Conroy, A. L., Namasopo, S., Kain, K. C., & Hawkes, M. T. (2023). Pediatric Malaria with Respiratory Distress: Prognostic Significance of Point-of-Care Lactate. Microorganisms, 11(4). https://doi.org/10.3390/microorganisms11040923
  6. Familiar-Lopez, I., Sikorskii, A., Chhaya, R., Holmes, A., Arima, E. G., Caesar, O. J., Nakasujja, N., & Boivin, M. J. (2023). Predictive validation of Ugandan infant eye-tracking test for memory of human faces. Child Neuropsychol, 29(3), 486-502. https://doi.org/10.1080/09297049.2022.2099537
  7. Nkosi-Gondwe, T., Robberstad, B., Opoka, R., Kalibbala, D., Rujumba, J., Galileya, L. T., Akun, P., Nambatya, W., Ssenkusu, J., TerKuile, F., Phiri, K., & Idro, R. (2023). Dihydroartemisinin-piperaquine or sulphadoxine-pyrimethamine for the chemoprevention of malaria in children with sickle cell anaemia in eastern and southern Africa (CHEMCHA): a protocol for a multi-centre, two-arm, double-blind, randomised, placebo-controlled superiority trial. Trials, 24(1), 257. https://doi.org/10.1186/s13063-023-07274-4
  8. Nabawanuka, E., Ameda, F., Erem, G., Bugeza, S., Opoka, R. O., Kiguli, S., Amorut, D., Aloroker, F., Olupot-Olupot, P., Mnjalla, H., Mpoya, A., & Maitland, K. (2023). Cardiovascular abnormalities in chest radiographs of children with pneumonia, Uganda. Bull World Health Organ, 101(3), 202-210. https://doi.org/10.2471/blt.22.288801
  9. Edridge, A., Namazzi, R., Tebulo, A., Mfizi, A., Deijs, M., Koekkoek, S., de Wever, B., van der Ende, A., Umiwana, J., de Jong, M. D., Jans, J., Verhoeven-Duif, N., Titulaer, M., van Karnebeek, C., Seydel, K., Taylor, T., Asiimwe-Kateera, B., van der Hoek, L., Kabayiza, J. C., . . . van Woensel, J. B. M. (2023). Viral, Bacterial, Metabolic, and Autoimmune Causes of Severe Acute Encephalopathy in Sub-Saharan Africa: A Multicenter Cohort Study. J Pediatr, 258, 113360. https://doi.org/10.1016/j.jpeds.2023.02.007
  10. Stefanova, V., Ngai, M., Weckman, A. M., Wright, J. K., Zhong, K., Richard-Greenblatt, M., McDonald, C. R., Conroy, A. L., Namasopo, S., Opoka, R. O., Hawkes, M., & Kain, K. C. (2023). Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria. Clin Infect Dis, 76(3), e1079-e1086. https://doi.org/10.1093/cid/ciac457
  11. Batte, A., Kasirye, P., Baluku, R., Kiguli, S., Kalyesubula, R., John, C. C., Schwaderer, A. L., Imel, E. A., & Conroy, A. L. (2022). Mineral bone disorders and kidney disease in hospitalized children with sickle cell anemia. Front Pediatr, 10, 1078853. https://doi.org/10.3389/fped.2022.1078853
  12. Okell, L. C., Kwambai, T. K., Dhabangi, A., Khairallah, C., Nkosi-Gondwe, T., Winskill, P., Opoka, R., Mousa, A., Kühl, M. J., Lucas, T. C. D., Challenger, J. D., Idro, R., Weiss, D. J., Cairns, M., Ter Kuile, F. O., Phiri, K., Robberstad, B., & Mori, A. T. (2023). Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa. Nat Commun, 14(1), 402. https://doi.org/10.1038/s41467-023-35939-

Publications 2022

  1. Idro, R., Boehme, A. K., Kawooya, M., Lubowa, S. K., Munube, D., Bangirana, P., Opoka, R., Mupere, E., Lignelli, A., Kasirye, P., Green, N. S., & Minja, F. J. (2022). Brain Magnetic Resonance Imaging and Angiography in Children with Sickle Cell Anaemia in Uganda in a Cross-Sectional Sample. J Stroke Cerebrovasc Dis, 31(4), 106343. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106343
  2. Conroy, A. L., Tran, T. M., Bond, C., Opoka, R. O., Datta, D., Liechty, E. A., Bangirana, P., Namazzi, R., Idro, R., Cusick, S., Ssenkusu, J. M., & John, C. C. (2022). Plasma Amino Acid Concentrations in Children With Severe Malaria Are Associated With Mortality and Worse Long-term Kidney and Cognitive Outcomes. J Infect Dis, 226(12), 2215-2225. https://doi.org/10.1093/infdis/jiac392
  3. Konrad, E. R., Soo, J., Conroy, A. L., Namasopo, S., Opoka, R. O., & Hawkes, M. T. (2022). Circulating markers of neutrophil activation and lung injury in pediatric pneumonia in low-resource settings. Pathog Glob Health, 1-9. https://doi.org/10.1080/20477724.2022.2160885
  4. Namazzi, R., Opoka, R., Datta, D., Bangirana, P., Batte, A., Berrens, Z., Goings, M. J., Schwaderer, A. L., Conroy, A. L., & John, C. C. (2022). Acute Kidney Injury Interacts With Coma, Acidosis, and Impaired Perfusion to Significantly Increase Risk of Death in Children With Severe Malaria. Clin Infect Dis, 75(9), 1511-1519. https://doi.org/10.1093/cid/ciac229
  5. Ngai, M., Hawkes, M. T., Erice, C., Weckman, A. M., Wright, J., Stefanova, V., Opoka, R. O., Namasopo, S., Conroy, A. L., & Kain, K. C. (2022). Intestinal Injury in Ugandan Children Hospitalized With Malaria. J Infect Dis, 226(11), 2010-2020. https://doi.org/10.1093/infdis/jiac340
  6. Sarangam, M. L., Namazzi, R., Datta, D., Bond, C., Vanderpool, C. P. B., Opoka, R. O., John, C. C., & Conroy, A. L. (2022). Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria. mBio, 13(5), e0132522. https://doi.org/10.1128/mbio.01325-22
  7. Kühl, M. J., Gondwe, T., Dhabangi, A., Kwambai, T. K., Mori, A. T., Opoka, R., John, C. C., Idro, R., Ter Kuile, F. O., Phiri, K. S., & Robberstad, B. (2022). Economic evaluation of postdischarge malaria chemoprevention in preschool children treated for severe anaemia in Malawi, Kenya, and Uganda: A cost-effectiveness analysis. EClinicalMedicine, 52, 101669. https://doi.org/10.1016/j.eclinm.2022.101669
  8. McDonald, C. R., Weckman, A. M., Richardson, E., Hawkes, M. T., Leligdowicz, A., Namasopo, S., Opoka, R. O., Conroy, A. L., & Kain, K. C. (2022). Sex as a determinant of disease severity and clinical outcome in febrile children under five presenting to a regional referral hospital in Uganda. PLoS One, 17(10), e0276234. https://doi.org/10.1371/journal.pone.0276234
  9. Batte, A., Menon, S., Ssenkusu, J. M., Kiguli, S., Kalyesubula, R., Lubega, J., Berrens, Z., Mutebi, E. I., Ogwang, R., Opoka, R. O., John, C. C., & Conroy, A. L. (2022). Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality. Kidney Int, 102(4), 885-893. https://doi.org/10.1016/j.kint.2022.05.020
  10. Uyoga, S., Olupot-Olupot, P., Connon, R., Kiguli, S., Opoka, R. O., Alaroker, F., Muhindo, R., Macharia, A. W., Dondorp, A. M., Gibb, D. M., Walker, A. S., George, E. C., Maitland, K., & Williams, T. N. (2022). Sickle cell anaemia and severe Plasmodium falciparum malaria: a secondary analysis of the Transfusion and Treatment of African Children Trial (TRACT). Lancet Child Adolesc Health, 6(9), 606-613. https://doi.org/10.1016/s2352-4642(22)00153-5
  11. McDonald, C. R., Leligdowicz, A., Conroy, A. L., Weckman, A. M., Richard-Greenblatt, M., Ngai, M., Erice, C., Zhong, K., Namasopo, S., Opoka, R. O., Hawkes, M. T., & Kain, K. C. (2022). Immune and endothelial activation markers and risk stratification of childhood pneumonia in Uganda: A secondary analysis of a prospective cohort study. PLoS Med, 19(7), e1004057. https://doi.org/10.1371/journal.pmed.1004057
  12. Conroy, A. L., Hawkes, M. T., Leligdowicz, A., Mufumba, I., Starr, M. C., Zhong, K., Namasopo, S., John, C. C., Opoka, R. O., & Kain, K. C. (2022). Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance. BMC Med, 20(1), 221. https://doi.org/10.1186/s12916-022-02410-4
  13. Blatt, D. B., Hanisch, B., Co, K., Datta, D., Bond, C., Opoka, R. O., Cusick, S. E., Michelow, I. C., & John, C. C. (2022). Impact of Oxidative Stress on Risk of Death and Readmission in African Children With Severe Malaria: A Prospective Observational Study. J Infect Dis, 226(4), 714-722. https://doi.org/10.1093/infdis/jiac234
  14. Watson, J. A., Uyoga, S., Wanjiku, P., Makale, J., Nyutu, G. M., Mturi, N., George, E. C., Woodrow, C. J., Day, N. P. J., Bejon, P., Opoka, R. O., Dondorp, A. M., John, C. C., Maitland, K., Williams, T. N., & White, N. J. (2022). Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations. Sci Transl Med, 14(654), eabn5040. https://doi.org/10.1126/scitranslmed.abn5040
  15. Mian, Q., Rahman Malik, S. M. M., Alinor, M. A., Hossain, M. S., Sharma, J. K., Hassan, O. M., Ahmed, A. M., Jama, A. A., Okello, A. J., Namasopo, S., Opoka, R. O., Conradi, N., Saleh, A., Conroy, A. L., & Hawkes, M. T. (2022). Implementation of solar powered oxygen delivery in a conflict zone: preliminary findings from Somalia on feasibility and usefulness. Med Confl Surviv, 38(2), 140-158. https://doi.org/10.1080/13623699.2022.2081056
  16. Hawkes, M. T., Leligdowicz, A., Batte, A., Situma, G., Zhong, K., Namasopo, S., Opoka, R. O., Kain, K. C., & Conroy, A. L. (2022). Pathophysiology of Acute Kidney Injury in Malaria and Non-Malarial Febrile Illness: A Prospective Cohort Study. Pathogens, 11(4). https://doi.org/10.3390/pathogens11040436
  17. Batte, A., Menon, S., Ssenkusu, J., Kiguli, S., Kalyesubula, R., Lubega, J., Mutebi, E. I., Opoka, R. O., John, C. C., Starr, M. C., & Conroy, A. L. (2022). Acute kidney injury in hospitalized children with sickle cell anemia. BMC Nephrol, 23(1), 110. https://doi.org/10.1186/s12882-022-02731-9
  18. Fernander, E. M., Adogamhe, P., Datta, D., Bond, C., Zhao, Y., Bangirana, P., Conroy, A. L., Opoka, R. O., & John, C. C. (2022). Elevated Plasma Soluble ST2 Levels are Associated With Neuronal Injury and Neurocognitive Impairment in Children With Cerebral Malaria. Pathog Immun, 7(1), 60-80. https://doi.org/10.20411/pai.v7i1.499
  19. George, E. C., Uyoga, S., M’Baya, B., Kyeyune Byabazair, D., Kiguli, S., Olupot-Olupot, P., Opoka, R. O., Chagaluka, G., Alaroker, F., Williams, T. N., Bates, I., Mbanya, D., Gibb, D. M., Walker, A. S., & Maitland, K. (2022). Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial. Lancet Glob Health, 10(3), e360-e368. https://doi.org/10.1016/s2214-109x(21)00565-9
  20. Ahmed, U., Soo, J., Conroy, A. L., Namasopo, S., Opoka, R. O., Bhargava, R., & Hawkes, M. T. (2022). Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings. Cytokine, 151, 155794. https://doi.org/10.1016/j.cyto.2022.155794
  21. Huang, K. Y., Nakigudde, J., Kisakye, E. N., Sentongo, H., Dennis-Tiwary, T. A., Tozan, Y., Park, H., & Brotman, L. M. (2022). Advancing scalability and impacts of a teacher training program for promoting child mental health in Ugandan primary schools: protocol for a hybrid-type II effectiveness-implementation cluster randomized trial. Int J Ment Health Syst, 16(1), 28. https://doi.org/10.1186/s13033-022-00538-7
  22. Konrad, E. R., Soo, J., Conroy, A. L., Namasopo, S., Opoka, R. O., & Hawkes, M. T. (2022). Interleukin-18 binding protein in infants and children hospitalized with pneumonia in low-resource settings. Cytokine, 150, 155775. https://doi.org/10.1016/j.cyto.2021.155775
  23. Familiar, I., Sikorskii, A., Chhaya, R., Weiss, J., Seffren, V., Ojuka, J. C., Awadu, J., & Boivin, M. J. (2022). Early Childhood Vigilance Test (ECVT) of attention in younger HIV-exposed Ugandan children predicts Tests of Variables of Attention (TOVA) at school age. Neuropsychology, 36(3), 185-194. https://doi.org/10.1037/neu0000788
  24. Namazzi, R., Batte, A., Opoka, R. O., Bangirana, P., Schwaderer, A. L., Berrens, Z., Datta, D., Goings, M., Ssenkusu, J. M., Goldstein, S. L., John, C. C., & Conroy, A. L. (2022). Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: A prospective cohort study. EClinicalMedicine, 44, 101292. https://doi.org/10.1016/j.eclinm.2022.101292

Publications 2021

  1. Leligdowicz, A., Conroy, A. L., Hawkes, M., Richard-Greenblatt, M., Zhong, K., Opoka, R. O., Namasopo, S., Bell, D., Liles, W. C., da Costa, B. R., Jüni, P., & Kain, K. C. (2021). Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test. Nat Commun, 12(1), 6832. https://doi.org/10.1038/s41467-021-27215-6
  2. Mandal, R. K., Denny, J. E., Namazzi, R., Opoka, R. O., Datta, D., John, C. C., & Schmidt, N. W. (2021). Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection. Cell Rep, 35(6), 109094. https://doi.org/10.1016/j.celrep.2021.109094
  3. Batte, A., Murphy, K. J., Namazzi, R., Co, K., Opoka, R. O., Ssenkusu, J. M., John, C. C., & Conroy, A. L. (2021). Evaluating kidney function using a point-of-care creatinine test in Ugandan children with severe malaria: a prospective cohort study. BMC Nephrol, 22(1), 369. https://doi.org/10.1186/s12882-021-02573-x
  4. Kiguli, S., Olopot-Olupot, P., Alaroker, F., Engoru, C., Opoka, R. O., Tagoola, A., Hamaluba, M., Mnjalla, H., Mpoya, A., Mogaka, C., Nalwanga, D., Nabawanuka, E., Nokes, J., Nyaigoti, C., Briend, A., van Woensel, J. B. M., Grieve, R., Sadique, Z., Williams, T. N., . . . Maitland, K. (2021). Children’s Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial. Wellcome Open Res, 6, 221. https://doi.org/10.12688/wellcomeopenres.17123.2
  5. Henrici, R. C., Sautter, C. L., Bond, C., Opoka, R. O., Namazzi, R., Datta, D., Ware, R. E., Conroy, A. L., & John, C. C. (2021). Decreased parasite burden and altered host response in children with sickle cell anemia and severe anemia with malaria. Blood Adv, 5(22), 4710-4720. https://doi.org/10.1182/bloodadvances.2021004704
  6. Mburu, W., Conroy, A. L., Cusick, S. E., Bangirana, P., Bond, C., Zhao, Y., Opoka, R. O., & John, C. C. (2021). The Impact of Undernutrition on Cognition in Children with Severe Malaria and Community Children: A Prospective 2-Year Cohort Study. J Trop Pediatr, 67(5). https://doi.org/10.1093/tropej/fmab091
  7. Datta, D., Bangirana, P., Opoka, R. O., Conroy, A. L., Co, K., Bond, C., Zhao, Y., Kawata, K., Saykin, A. J., & John, C. C. (2021). Association of Plasma Tau With Mortality and Long-term Neurocognitive Impairment in Survivors of Pediatric Cerebral Malaria and Severe Malarial Anemia. JAMA Netw Open, 4(12), e2138515. https://doi.org/10.1001/jamanetworkopen.2021.38515
  8. Ezeamama, A. E., Zalwango, S. K., Sikorskii, A., Tuke, R., Musoke, P. M., Giordani, B., & Boivin, M. J. (2021). In utero and peripartum antiretroviral exposure as predictor of cognition in 6- to 10-year-old HIV-exposed Ugandan children – a prospective cohort study. HIV Med, 22(7), 592-604. https://doi.org/10.1111/hiv.13094
  9. Ikekwere, J., Ucheagwu, V., Familiar-Lopez, I., Sikorskii, A., Awadu, J., Ojuka, J. C., . . . Boivin, M. J. (2021). Attention Test Improvements from a Cluster Randomized Controlled Trial of Caregiver Training for HIV-Exposed/Uninfected Ugandan Preschool Children. J Pediatr, 235, 226-232. doi:10.1016/j.jpeds.2021.03.064
  10. Connon, R., George, E. C., Olupot-Olupot, P., Kiguli, S., Chagaluka, G., Alaroker, F., . . . Walker, A. S. (2021). Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data. BMC Public Health, 21(1), 1480. doi:10.1186/s12889-021-11481-6
  11. Conroy, A. L., Opoka, R. O., Bangirana, P., Namazzi, R., Okullo, A. E., Georgieff, M. K., . . . John, C. C. (2021). Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria. BMC Med, 19(1), 168. doi:10.1186/s12916-021-02033-1
  12. Bangirana, P., Birabwa, A., Nyakato, M., Nakitende, A. J., Kroupina, M., Ssenkusu, J. M., . . . Idro, R. (2021). Use of the creating opportunities for parent empowerment programme to decrease mental health problems in Ugandan children surviving severe malaria: a randomized controlled trial. Malar J, 20(1), 267. doi:10.1186/s12936-021-03795-y
  13. Huang, Y., Mian, Q., Conradi, N., Opoka, R. O., Conroy, A. L., Namasopo, S., & Hawkes, M. T. (2021). Estimated Cost-effectiveness of Solar-Powered Oxygen Delivery for Pneumonia in Young Children in Low-Resource Settings. JAMA Netw Open, 4(6), e2114686. doi:10.1001/jamanetworkopen.2021.14686
  14. Maitland, K., Kiguli, S., Olupot-Olupot, P., Opoka, R. O., Chimalizeni, Y., Alaroker, F., Uyoga, S., Kyeyune-Byabazaire, D., M’Baya, B., Bates, I., Williams, T. N., Munube, D., Mbanya, D., Molyneux, E. M., South, A., Walker, A. S., Gibb, D. M., & George, E. C. (2021). Transfusion management of severe anaemia in African children: a consensus algorithm. Br J Haematol, 193(6), 1247-1259. https://doi.org/10.1111/bjh.17429
  15. Mandal, R. K., Denny, J. E., Namazzi, R., Opoka, R. O., Datta, D., John, C. C., & Schmidt, N. W. (2021). Dynamic modulation of spleen germinal center reactions by gut bacteria during Plasmodium infection. Cell Rep, 35(6), 109094. doi:10.1016/j.celrep.2021.109094
  16. Nalwanga, D., Musiime, V., Bangirana, P., Nishiguchi, E. P., Kiggwe, A., Ssesanga, T., Ssenkusu, J. M., Musoke, P., & Cusick, S. E. (2021). Neurocognitive function among HIV-infected children on protease inhibitor -based versus non-protease inhibitor based antiretroviral therapy in Uganda: a pilot study. BMC Pediatr, 21(1), 198. https://doi.org/10.1186/s12887-021-02676-2
  17. Maitland, K., Kiguli, S., Olupot-Olupot, P., Hamaluba, M., Thomas, K., Alaroker, F., . . . Rowan, K. (2021). Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia. Intensive Care Med, 47(5), 566-576. doi:10.1007/s00134-021-06385-3
  18. Familiar, I., Majumder, A., Sikorskii, A., Boivin, M., Nakasujja, N., & Bass, J. (2021). Longitudinal Dyadic Interdependence in Depression Symptoms of Caregivers Living with HIV in Uganda and Their Dependent Children’s Neurodevelopment and Executive Behavior Outcomes. AIDS Behav. doi:10.1007/s10461-021-03192-1
  19. Sirajee, R., Conroy, A. L., Namasopo, S., Opoka, R. O., Lavoie, S., Forgie, S., . . . Hawkes, M. T. (2021). Growth Faltering and Developmental Delay in HIV-Exposed Uninfected Ugandan Infants: A Prospective Cohort Study. J Acquir Immune Defic Syndr, 87(1), 730-740. doi:10.1097/qai.0000000000002626
  20. Mejia, P., Treviño-Villarreal, J. H., De Niz, M., Meibalan, E., Longchamp, A., Reynolds, J. S., . . . Mitchell, J. R. (2021). Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria. Sci Adv, 7(13). doi:10.1126/sciadv.abe2484
  21. Ouma, B. J., Bangirana, P., Ssenkusu, J. M., Datta, D., Opoka, R. O., Idro, R., . . . Conroy, A. L. (2021). Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria. Malar J, 20(1), 17. doi:10.1186/s12936-020-03545-

Publications 2020

  1. Kwambai, T. K., Dhabangi, A., Idro, R., Opoka, R., Watson, V., Kariuki, S., . . . Ter Kuile, F. O. (2020). Malaria Chemoprevention in the Postdischarge Management of Severe Anemia. N Engl J Med, 383(23), 2242-2254. doi:10.1056/NEJMoa2002820
  2. Villaverde, C., Namazzi, R., Shabani, E., Park, G. S., Datta, D., Hanisch, B., . . . John, C. C. (2020). Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria. J Pediatric Infect Dis Soc, 9(5), 580-586. doi:10.1093/jpids/piz082
  3. Ssemata, A. S., Opoka, R. O., Ssenkusu, J. M., Nakasujja, N., John, C. C., & Bangirana, P. (2020). Neurodevelopmental performance among pre-schoolers treated for severe anaemia at Lira Regional Referral Hospital, Uganda. PLoS One, 15(11), e0240694. doi:10.1371/journal.pone.0240694
  4. Ssemata, A. S., Opoka, R. O., Ssenkusu, J. M., Nakasujja, N., John, C. C., & Bangirana, P. (2020). Socio-emotional and adaptive behaviour in children treated for severe anaemia at Lira Regional Referral Hospital, Uganda: a prospective cohort study. Child Adolesc Psychiatry Ment Health, 14(1), 45. doi:10.1186/s13034-020-00352-4
  5. Batte, A., Starr, M. C., Schwaderer, A. L., Opoka, R. O., Namazzi, R., Phelps Nishiguchi, E. S., . . . Conroy, A. L. (2020). Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study. BMC Nephrol, 21(1), 417. doi:10.1186/s12882-020-02076-1
  6. Opoka, R. O., Conroy, A. L., Waiswa, A., Wasswa, R., Tumwine, J. K., Karamagi, C., & John, C. C. (2020). Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda. Am J Trop Med Hyg, 103(6), 2574-2580. doi:10.4269/ajtmh.20-0199
  7. Ouma, B. J., Ssenkusu, J. M., Shabani, E., Datta, D., Opoka, R. O., Idro, R., . . . Conroy, A. L. (2020). Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria. Crit Care Med, 48(9), e734-e743. doi:10.1097/ccm.0000000000004469
  8. Ssemata, A. S., Nakitende, J. A., Kizito, S., Whipple, E. C., Bangirana, P., Nakasujja, N., . . . McHenry, M. S. (2020). Associations of childhood exposure to malaria with cognition and behavior outcomes: a systematic review protocol. Syst Rev, 9(1), 174. doi:10.1186/s13643-020-01434-2
  9. Zhang, R., Rai, U., Ibrahim, N. B. M., Amazouz, Y., Soo, J., Conroy, A. L., . . . Hawkes, M. T. (2020). Dysregulation of angiopoietin-Tie-2 axis in ugandan children hospitalized with pneumonia. Cytokine, 133, 155175. doi:10.1016/j.cyto.2020.155175
  10. John, C. C., Opoka, R. O., Latham, T. S., Hume, H. A., Nabaggala, C., Kasirye, P., . . . Ware, R. E. (2020). Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa. N Engl J Med, 382(26), 2524-2533. doi:10.1056/NEJMoa2000146
  11. Batte, A., Starr, M. C., Schwaderer, A. L., Opoka, R. O., Namazzi, R., Phelps Nishiguchi, E. S., . . . Conroy, A. L. (2020). Methods to estimate baseline creatinine and define acute kidney injury in lean Ugandan children with severe malaria: a prospective cohort study. BMC Nephrol, 21(1), 417. doi:10.1186/s12882-020-02076-1
  12. Opoka, R. O., Waiswa, A., Harriet, N., John, C. C., Tumwine, J. K., & Karamagi, C. (2020). Blackwater Fever in Ugandan Children With Severe Anemia is Associated With Poor Postdischarge Outcomes: A Prospective Cohort Study. Clin Infect Dis, 70(11), 2247-2254. doi:10.1093/cid/ciz64
  13. Ssemata, A. S., Hickson, M., Ssenkusu, J. M., Cusick, S. E., Nakasujja, N., Opoka, R. O., Kroupina M, Georgieff MK, Bangirana P, John, C. C. (2020). Delayed iron does not alter cognition or behavior among children with severe malaria and iron deficiency. Pediatr Res. doi:10.1038/s41390-020-0957-8
  14. Tuke, R., Sikorskii, A., Zalwango, S. K., Webster, K. D., Ismail, A., Pobee, R. A., . . . Ezeamama, A. E. (2020). Psychosocial Adjustment in Ugandan Children: Coping With Human Immunodeficiency Virus Exposure, Lifetime Adversity, and Importance of Social Support. New Dir Child Adolesc Dev, 2020(171), 55-75. doi:10.1002/cad.2035
  15. Cusick, S. E., Opoka, R. O., Ssemata, A. S., Georgieff, M. K., & John, C. C. (2020). Delayed iron improves iron status without altering malaria risk in severe malarial anemia. Am J Clin Nutr. Am J Clin Nutr, 111(5), 1059-1067. doi:10.1093/ajcn/nqaa004
  16. Opoka, R. O., Conroy, A. L., Waiswa, A., Wasswa, R., Tumwine, J. K., Karamagi, C., & John, C. C. (2020). Severe Anemia Is Associated with Systemic Inflammation in Young Children Presenting to a Tertiary Hospital in Uganda. Am J Trop Med Hyg, 103(6), 2574-2580. doi:10.4269/ajtmh.20-0199
  17. Postels, D. G., Osei-Tutu, L., Seydel, K. B., Xu, Q., Li, C., Taylor, T. E., . . . Wilson, M. R. (2020). Central Nervous System Virus Infection in African Children with Cerebral Malaria. Am J Trop Med Hyg, 103(1), 200-205. doi:10.4269/ajtmh.19-0962
  18. Datta D, Conroy AL, Castelluccio PF, Ssenkusu JM, Park GS, Opoka RO, Bangirana P, Idro R, Saykin AJ, John CC. (2020). Elevated cerebrospinal fluid tau protein concentrations on admission are associated with long-term neurologic and cognitive impairment in Ugandan children with cerebral malaria. Clin Infect Dis, 70(6), 1161-1168. doi:10.1093/cid/ciz32
  19. Boivin, M. J., Augustinavicius, J. L., Familiar-Lopez, I., Murray, S. M., Sikorskii, A., Awadu, J., . . . Bass, J. K. (2020). Early Childhood Development Caregiver Training and Neurocognition of HIV-Exposed Ugandan Siblings. J Dev Behav Pediatr. Apr;41(3):221-229. doi: 10.1097/DBP.0000000000000753.
  20. Augustinavicius, J. L., Murray, S. M., Familiar-Lopez, I., Boivin, M. J., Mutebe, A., Arima, E., & Bass, J. K. (2020). Measurement of Parenting Self-efficacy Among Female HIV-Affected Caregivers in Uganda. Matern Child Health J, 24(3), 319-327. doi:10.1007/s10995-019-02855-9
  21. Hawkes, M. T., Opoka, R. O., Conroy, A. L., Elphinstone, R. E., Hume, H. A., Namasopo, S., & Kain, K. C. (2020). Anemia and transfusion requirements among Ugandan children with severe malaria treated with intravenous artesunate. Pediatr Hematol Oncol, 1-13. doi:10.1080/08880018.2019.1701161

Publications 2019

  1. Hickson, M. R., Conroy, A. L., Bangirana, P., Opoka, R. O., Idro, R., Ssenkusu, J. M., & John, C. C. (2019). Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems. PLoS One, 14(12), e0226405. doi:10.1371/journal.pone.0226405
  2. Villaverde, C., Namazzi, R., Shabani, E., Park, G. S., Datta, D., Hanisch, B., . . . John, C. C. (2019). Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria. J Pediatric Infect Dis Soc. doi:10.1093/jpids/piz082
  3. Conradi, N., Mian, Q., Namasopo, S., Conroy, A. L., Hermann, L. L., Olaro, C., . . . Hawkes, M. T. (2019). Solar-powered oxygen delivery for the treatment of children with hypoxemia: protocol for a cluster-randomized stepped-wedge controlled trial in Uganda. Trials, 20(1), 679. doi:10.1186/s13063-019-3752-2
  4. Green, N. S., Munube, D., Bangirana, P., Buluma, L. R., Kebirungi, B., Opoka, R., . . . Idro, R. (2019). Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study. BMC Pediatr, 19(1), 381. doi:10.1186/s12887-019-1758-2
  5. Opoka, R. O., Hume, H. A., Latham, T. S., Lane, A., Williams, O., Tymon, J., . . . Ware, R. E. (2019). Hydroxyurea to lower TCD velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort. Haematologica. doi:10.3324/haematol.2019.231407
  6. Rivera-Correa, J., Conroy, A. L., Opoka, R. O., Batte, A., Namazzi, R., Ouma, B., . . . Rodriguez, A. (2019). Autoantibody levels are associated with acute kidney injury, anemia and post-discharge morbidity and mortality in Ugandan children with severe malaria. Sci Rep, 9(1), 14940. doi:10.1038/s41598-019-51426-z
  7. Maitland, K., Olupot-Olupot, P., Kiguli, S., Chagaluka, G., Alaroker, F., Opoka, R. O., . . . Walker, A. S. (2019). Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial. Lancet Glob Health, 7(10), e1435-e1447. doi:10.1016/s2214-109x(19)30345-6
  8. Maitland, K., Olupot-Olupot, P., Kiguli, S., Chagaluka, G., Alaroker, F., Opoka, R. O., . . . Walker, A. S. (2019). Transfusion Volume for Children with Severe Anemia in Africa. N Engl J Med, 381(5), 420-431. doi:10.1056/NEJMoa1900100
  9. Maitland, K., Kiguli, S., Olupot-Olupot, P., Engoru, C., Mallewa, M., Saramago Goncalves, P., . . . Walker, A. S. (2019). Immediate Transfusion in African Children with Uncomplicated Severe Anemia. N Engl J Med, 381(5), 407-419. doi:10.1056/NEJMoa1900105
  10. Opoka, R. O., Waiswa, A., Harriet, N., John, C. C., Tumwine, J. K., & Karamagi, C. (2019). Blackwater fever in Ugandan children with severe anemia is associated with poor post-discharge outcomes. A prospective cohort study. Clin Infect Dis. doi:10.1093/cid/ciz64
  11. Carman, A. S., Sautter, C., Anyanwu, J. N., Ssemata, A. S., Opoka, R. O., Ware, R. E., … & John, C. C. (2019). Perceived benefits and risks of participation in a clinical trial for Ugandan children with sickle cell anemia. Pediatric blood & cancer, e27830.
  12. Sawatzky, J., Soo, J., Conroy, A. L., Bhargava, R., Namasopo, S., Opoka, R. O., & Hawkes, M. T. (2019). Biomarkers of Systemic Inflammation in Ugandan Infants and Children Hospitalized With Respiratory Syncytial Virus Infection. Pediatr Infect Dis J, 38(8), 854-859. doi:10.1097/inf.0000000000002343
  13. Boivin, M. J., Sikorskii, A., Nakasujja, N., Ruiseñor-Escudero, H., Familiar-Lopez, I., Opoka, R. O., & Giordani, B. (2019). Evaluating Immunopathogenic Biomarkers During Severe Malaria Illness as Modifiers of the Neuropsychologic Benefits of Computer Cognitive Games Rehabilitation in Ugandan Children. The Pediatric Infectious Disease Journal
  14. Conroy AL, Opoka RO, Bangirana P, Idro R, Ssenkusu JM, Datta D, Hodges JS, Morgan C, John CC. (2019). Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria. BMC medicine, 17(1):98.
  15. Augustinavicius JL, Familiar-Lopez I, Winch PJ, Murray SM, Ojuka C, Boivin MJ, Bass JK: Parenting self-efficacy in the context of poverty and HIV in Eastern Uganda: A qualitative study. Infant mental health journal 2019, 40(3):422-438.
  16. Uyoga S, Mpoya A, Olupot-Olupot P, Kiguli S, Opoka RO, Engoru C, Mallewa M, Kennedy N, M’Baya B, Kyeyune D et al: Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa. Vox sanguinis 2019.
  17. Bangirana P, Giordani B, Kobusingye O, Murungyi L, Mock C, John CC, Idro R (2019). Patterns of traumatic brain injury and six-month neuropsychological outcomes in Uganda. BMC Neurology, 19(1):18.
  18. Conroy AL, Bangirana P, Muhindo MK, Kakuru A, Jagannathan P, Opoka RO, Liechty EA, Nakalembe M, Kamya MR, Dorsey G et al: Case Report: Birth Outcome and Neurodevelopment in Placental Malaria Discordant Twins. The American journal of tropical medicine and hygiene 2019Mar;100(3):552-555
  19. Datta, D., Namazzi, R., Conroy, A. L., Cusick, S. E., Hume, H. A., Tagoola, A., . . . John, C. C. (2019). Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia. Trials, 20(1), 460. doi:10.1186/s13063-019-3569-z
  20. Boivin MJ, Nakasujja N, Sikorskii A, Ruisenor-Escudero H, Familiar-Lopez I, Walhof K, van der Lugt EM, Opoka RO, Giordani B: Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial. Brain research bulletin 2019, 145:117-128.
  21. Dhabangi A, Idro R, John CC, Dzik WH, Opoka R, Siu GE, Ayebare F, van Hensbroek MB: Caregivers and community perceptions of blood transfusion for children with severe anaemia in Uganda. Transfusion medicine (Oxford, England) 2019, 29(1):61-67.
  22. Opoka RO, Ssemata AS, Oyang W, Nambuya H, John CC, Karamagi C, Tumwine JK: Adherence to clinical guidelines is associated with reduced inpatient mortality among children with severe anemia in Ugandan hospitals. PloS one. vol. 14; 2019: e0210982
  23. Dhabangi A, Idro R, John CC, Dzik WH, Opoka R, Ssenyonga R, van Hensbroek MB: Risk factors for recurrent severe anemia among previously transfused children in Uganda: an age-matched case-control study. BMC pediatrics 2019, 19(1):27.
  24. Dhabangi A, Idro R, John CC, Dzik WH, Siu GE, Opoka RO, Ayebare F, van Hensbroek MB: Community perceptions of paediatric severe anaemia in Uganda. PLoS One 2019, 14(1):e0209476.
  25. Nallandhighal S, Park GS, Ho YY, Opoka RO, John CC, Tran TM: Whole-Blood Transcriptional Signatures Composed of Erythropoietic and NRF2-Regulated Genes Differ Between Cerebral Malaria and Severe Malarial Anemia. The Journal of infectious diseases 2019, 219(1):154-164.
  26. Ma C, Gunaratnam LC, Ericson A, Conroy AL, Namasopo S, Opoka RO, Hawkes MT: Handheld Point-of-Care Lactate Measurement at Admission Predicts Mortality in Ugandan Children Hospitalized with Pneumonia: A Prospective Cohort Study. The American journal of tropical medicine and hygiene 2019, Jan;100(1):37-42.

Publications 2018

1. Ruisenor-Escudero H, Sikorskii A, Familiar-Lopez I, Persaud D, Ziemniak C, Nakasujja N, Opoka R, Boivin M: Neurodevelopmental Outcomes in Pre-School Children Living with HIV-1 Subtypes A and D in Uganda. The Pediatric infectious disease journal 2018, 37(12):e298-e303.

2. Kwambai TK, Dhabangi A, Idro R, Opoka R, Kariuki S, Samuels AM, Desai M, van Hensbroek MB, John CC, Robberstad B et al: Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the post-discharge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial. Trials 2018, 19(1):610.

3. Ruisenor-Escudero H, Familiar I, Nyakato M, Kutessa A, Namukooli J, Ssesanga T, Joyce C, Laughton B, Grab J, Chernoff M et al: Building capacity in neurodevelopment assessment of children in sub-Saharan Africa: A quality assurance model to implement standardized neurodevelopment testing. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence 2018:1-16.

4. Chen CJ, Bakeera-Kitaka S, Mupere E, Kasirye P, Munube D, Idro R, Hume H, Pfeffer B, LaRussa P, Green NS: Paediatric immunisation and chemoprophylaxis in a Ugandan sickle cell disease clinic. Journal of paediatrics and child health 2018.

5. Nakitende AJ, Bangirana P, Nakasujja N, Semrud-Clikeman M, Ssemata AS, John CC, Idro R: “I feel so bad but have nothing to do.” Exploring Ugandan caregivers’ experiences of parenting a child with severe malaria and subsequent repeated uncomplicated malaria. Malaria journal 2018, 17(1):360.

6. Nallandhighal S, Park GS, Ho YY, Opoka RO, John CC, Tran TM: Whole-blood transcriptional signatures composed of erythropoietic and Nrf2-regulated genes differ between cerebral malaria and severe malarial anemia. The Journal of infectious diseases 2018.

7. Gladding SP, McGann PT, Summer A, Russ CM, Uwemedimo OT, Matamoros Aguilar M, Chakraborty R, Moore M, Lieh-Lai M, Opoka R et al: The Collaborative Role of North American Departments of Pediatrics in Global Child Health. Pediatrics 2018, 142(1).

8. Hawkes MT, Conroy AL, Namasopo S, Bhargava R, Kain KC, Mian Q, Opoka RO: Solar-Powered Oxygen Delivery in Low-Resource Settings: A Randomized Clinical Noninferiority Trial. JAMA pediatrics 2018, 172(7):694-696.

9. Opoka RO, Ssemata AS, Oyang W, Nambuya H, John CC, Tumwine JK, Karamagi C: High rate of inappropriate blood transfusions in the management of children with severe anemia in Ugandan hospitals. BMC health services research 2018, 18(1):566.

10. Postels DG, Wu X, Li C, Kaplan PW, Seydel KB, Taylor TE, Kousa YA, Idro R, Opoka R, John CC et al: Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes. Malaria journal 2018, 17(1):208.

11. Cusick SE, Jaramillo EG, Moody EC, Ssemata AS, Bitwayi D, Lund TC, Mupere E: Assessment of blood levels of heavy metals including lead and manganese in healthy children living in the Katanga settlement of Kampala, Uganda. BMC public health 2018, 18(1):717.

12. Aramburo A, Todd J, George EC, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G et al: Lactate clearance as a prognostic marker of mortality in severely ill febrile children in East Africa. BMC medicine 2018, 16(1):37.

13. Finn K, Lori J, Lee M, Giordani B: Interdisciplinary Ugandan perspectives on computerized intervention implementation for child survivors of severe malaria: A qualitative analysis. Applied nursing research : ANR 2018, 39:154-159.

14. Seffren V, Familiar I, Murray SM, Augustinavicius J, Boivin MJ, Nakasujja N, Opoka R, Bass J: Association between coping strategies, social support, and depression and anxiety symptoms among rural Ugandan women living with HIV/AIDS. AIDS care 2018, 30(7):888-895.

15. Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC: Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria. Malaria journal 2018, 17(1):82

16. Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC. Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial. PLoS One 2018;13:e0191550.

17. Opoka RO, Bangirana P, Idro R, Shabani E, Namazzi R, John CC: Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia. Pediatric Blood & Cancer 2018, 65(1).

18. Chhaya, R., Weiss, J., Seffren, V., Sikorskii, A., Winke, P. M., Ojuka, J. C., & Boivin, M. J. (2017). The feasibility of an automated eye-tracking-modified Fagan test of memory for human faces in younger Ugandan HIV-exposed children. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence 2018, 24(5):686-701.

Publications 2017

1. Huang KY, Nakigudde J, Rhule D, Gumikiriza-Onoria JL, Abura G, Kolawole B, Ndyanabangi S, Kim S, Seidman E, Ogedegbe Get al: Transportability of an Evidence-Based Early Childhood Intervention in a Low-Income African Country: Results of a Cluster Randomized Controlled Study. Prevention science : the official journal of the Society for Prevention Research 2017, 18(8):964-975.

2. Bangirana P, Ruel TD, Boivin MJ, Pillai SK, Giron LB, Sikorskii A, Banik A, Achan J: Absence of neurocognitive disadvantage associated with paediatric HIV subtype A infection in children on antiretroviral therapy. Journal of the International AIDS Society 2017, 20:e25015

3. Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN et al: Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome open research 2017, 2:100.

4. Opoka RO, Ndugwa CM, Latham TS, Lane A, Hume HA, Kasirye P, Hodges JS, Ware RE, John CC: Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia. Blood 2017, 130:2585-93

5. Boivin MJ, Nakasujja N, Familiar-Lopez I, Murray SM, Sikorskii A, Awadu J, Shohet C, Givon D, Ruisenor-Escudero H, Schut EE et al: Effect of Caregiver Training on the Neurodevelopment of HIV-Exposed Uninfected Children and Caregiver Mental Health: A Ugandan Cluster-Randomized Controlled Trial. Journal of developmental and behavioral pediatrics 2017, 38:753-64

6. Jaramillo EG, Mupere E, Opoka RO, Hodges JS, Lund TC, Georgieff MK, John CC, Cusick SE: Delaying the start of iron until 28 days after antimalarial treatment is associated with lower incidence of subsequent illness in children with malaria and iron deficiency. PLoS One 2017, 12(8):e0183977.

7. Shabani E, Hanisch B, Opoka RO, Lavstsen T, John CC: Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria. BMC medicine 2017, 15(1):183.

8. Park GS, Opoka RO, Shabani E, Wypyszynski A, Hanisch B, John CC: Plasmodium falciparum histidine-rich protein-2 plasma concentrations are higher in retinopathy-negative cerebral malaria than in severe malarial anemia. In: Open Forum Infectious Diseases: 2017, 4(3):ofx151-ofx151.

9. Semrud-Clikeman M, Romero RAA, Prado EL, Shapiro EG, Bangirana P, John CC: Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries. Child Neuropsychology 2017, 23(7):761-802.

10. Tumukunde VS, Kiboneka E, John CC, Opoka RO, Idro R: Use of pre-hospital medication in children presenting with malaria to the emergency unit of Mulago Hospital, Uganda: A descriptive study. MalariaWorld journal 2017, 8.

11. Holmberg D, Franzén-Röhl E, Idro R, Opoka RO, Bangirana P, Sellgren CM, Wickström R, Färnert A, Schwieler L, Engberg G et al: Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria. Malaria journal 2017, 16(1):303.

12. Ssemata AS, Gladding S, John CC, Kiguli S: Developing mentorship in a resource-limited context: a qualitative research study of the experiences and perceptions of the makerere university student and faculty mentorship programme. BMC medical education 2017, 17(1):123.

13. Opoka RO, Hamre KES, Brand N, Bangirana P, Idro R, John CC: High Postdischarge Morbidity in Ugandan Children With Severe Malarial Anemia or Cerebral Malaria. Journal of the Pediatric Infectious Diseases Society 2017, 6(3):e41-e48.

14. Boivin, M. J., Weiss, J., Chhaya, R., Seffren, V., Awadu, J., Sikorskii, A., & Giordani, B. (2017). The feasibility of automated eye tracking with the Early Childhood Vigilance Test of attention in younger HIV-exposed Ugandan children. Neuropsychology, 31(5), 525-534. doi: 10.1037/neu0000382

15. Huang KY, Abura G, Theise R, Nakigudde J: Parental Depression and Associations with Parenting and Children’s Physical and Mental Health in a Sub-Saharan African Setting. .Child psychiatry and human development 2017, 48(4):517-527.

16. Bass JK, Opoka R, Familiar I, Nakasujja N, Sikorskii A, Awadu J, Givon D, Shohet C, Murray SM, Augustinavicius J et al: Randomized controlled trial of caregiver training for HIV-infected child neurodevelopment and caregiver well-being. AIDS (London, England) 2017, 31(13):1877-1883.

17. Shabani E, Ouma BJ, Idro R, Bangirana P, Opoka RO, Park GS, Conroy AL, John CC: Elevated cerebrospinal fluid tumor necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria. Parasite Immunology 2017, 39(7).

18. Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R et al: High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64(7):939-946.

19. Villaverde C, Namazzi R, Shabani E, Opoka RO, John CC: Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria. The American journal of tropical medicine and hygiene 2017, 96(5):1176-1184..

20. Murray SM, Familiar I, Nakasujja N, Winch PJ, Gallo JJ, Opoka R, Caesar JO, Boivin MJ, Bass JK: Caregiver mental health and HIV-infected child wellness: perspectives from Ugandan caregivers. AIDS care 2017, 29(6):793-799.

21. Olupot-Olupot P, Engoru C, Uyoga S, Muhindo R, Macharia A, Kiguli S, Opoka RO, Akech S, Ndila C, Nyeko R et al: High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017, 64(7):939-946.

22. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC: Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. PLoS One 2017, 12(4):e0175130.

23. Huang K-Y, Abura G, Theise R, Nakigudde J: Parental Depression and Associations with Parenting and Children’s Physical and Mental Health in a Sub-Saharan African Setting. Child psychiatry and human development 2017, 48(4):517-527

24. McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC: Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria. The Pediatric infectious disease journal 2017, 36(2):146-150.

25. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: B-type natriuretic peptide and plasma hemoglobin levels following transfusion of shorter-storage versus longer-storage red blood cells: Results from the TOTAL randomized trial. American heart journal 2017, 183:129-136.

Publications 2016

1. Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC et al: Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial. BMC Pediatrics 2016, 16(1):177.

2. Brand NR, Opoka RO, Hamre KE, John CC: Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality. PLOS ONE 2016, 11(9):e0163728.

3. Ssenkusu JM, Hodges JS, Opoka RO, Idro R, Shapiro E, John CC, Bangirana P: Long-term Behavioral Problems in Children With Severe Malaria. Pediatrics 2016: Nov;138(5).

4. Familiar I, Murray S, Ruisenor-Escudero H, Sikorskii A, Nakasujja N, Boivin MJ, Opoka R, Bass JK: Socio-demographic correlates of depression and anxiety among female caregivers living with HIV in rural Uganda. AIDS Care 2016, 28(12):1541-1545.

5. Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC: Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria. J Infect Dis 2016, 214(8):1268-1275

6. Cusick SE, John CC: Iron, Inflammation, and Malaria in the Pregnant Woman and Her Child: Saving Lives, Saving Brains. Am J Trop Med Hyg 2016, 95(4):739-740.

7. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: Cerebral Oximetry in Ugandan Children With Severe Anemia: Clinical Categories and Response to Transfusion. JAMA Pediatr 2016, 170(10):995-1002.

8. Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE et al: Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria. Science translational medicine 2016, 8(358):358ra128.

9. Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC et al: Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria. Open forum infectious diseases 2016, 3(3):ofw134.

10. Cusick SE, Opoka RO, Abrams SA, John CC, Georgieff MK, Mupere E: Delaying Iron Therapy until 28 Days after Antimalarial Treatment Is Associated with Greater Iron Incorporation and Equivalent Hematologic Recovery after 56 Days in Children: A Randomized Controlled Trial. J Nutr 2016, 146(9):1769-1774.

11. Anyanwu JN, Williams O, Sautter CL, Kasirye P, Hume H, Opoka RO, Latham T, Ndugwa C, Ware RE, John CC: Novel Use of Hydroxyurea in an African Region With Malaria: Protocol for a Randomized Controlled Clinical Trial. JMIR research protocols 2016, 5(2):e110

12. Shabani E, Opoka RO, Bangirana P, Park GS, Vercellotti GM, Guan W, Hodges JS, Lavstsen T, John CC: The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria. Scientific Reports 2016, 6:27084.

13. Idro R, Kakooza-Mwesige A, Asea B, Ssebyala K, Bangirana P, Opoka RO, Lubowa SK, Semrud-Clikeman M, John CC, Nalugya J: Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort. Malaria Journal 2016, 15(1):1-11.

14. Boivin MJ, Nakasujja N, Sikorskii A, Opoka RO, Giordani B: A Randomized Controlled Trial to Evaluate if Computerized Cognitive Rehabilitation Improves Neurocognition in Ugandan Children with HIV. AIDS Research and Human Retroviruses 2016, 32(8):743-755.

15. Boivin MJ, Sikorskii A, Familiar-Lopez I, Ruiseñor-Escudero H, Muhindo M, Kapisi J, Bigira V, Bass JK, Opoka RO, Nakasujja N: Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan children. Malaria Journal 2016, 15(1):1.

16. Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC: Acute kidney injury is common in pediatric severe malaria and is associated with increased risk of acute and long-term mortality: a prospective cohort study. In: Open Forum Infectious Diseases: 2016, 3(2):ofw046-ofw046

17. Turnbull H, Conroy A, Opoka RO, Namasopo S, Kain KC, Hawkes M: Solar-powered oxygen delivery: proof of concept. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016, 20(5):696-703.

18. Bass JK, Nakasujja N, Familiar-Lopez I, Sikorskii A, Murray SM, Opoka R, Augustinavicius J, Boivin MJ: Association of caregiver quality of care with neurocognitive outcomes in HIV-affected children aged 2-5 years in Uganda. AIDS Care 2016:1-8.

19. Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, Lopez JA, Liles WC: Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial. Malaria journal 2016, 15:56

20. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, John CC: Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children. Learning and Individual Differences 2016, 46:38-44.

21. Familiar I, Nakasujja N, Bass J, Sikorskii A, Murray SM, Ruisenor-Escudero H, Bangirana P, Opoka R, Boivin MJ: Caregivers’ depressive symptoms and parent-report of child executive function among young children in Uganda. Learn Individ Differ 2016, 46:17-24

Publications 2015

1. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, Ddungu H, Kyeyune D, Musisi E, Opoka R, Stowell CP, Dzik WH: Effect of Transfusion of Red Blood Cells With Longer vs Shorter Storage Duration on Elevated Blood Lactate Levels in Children With Severe Anemia: The TOTAL Randomized Clinical Trial. JAMA 2015, 314(23):2514-2523.

2. Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B et al: Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial. Trials 2015, 16(1):593.

3. John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK: Global research priorities for infections that affect the nervous system. Nature 2015, 527(7578):S178-S186.

4. Hawkes MT, Conroy AL, Opoka RO, Hermann L, Thorpe KE, McDonald C, Kim H, Higgins S, Namasopo S, John C et al: Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial. Malaria journal 2015, 14(1):421.

5. Bangirana P, Sikorskii A, Giordani B, Nakasujja N, Boivin MJ: Validation of the CogState battery for rapid neurocognitive assessment in Ugandan school age children. Child and adolescent psychiatry and mental health 2015, 9(1):1-7.

6. Ruiseñor-Escudero H, Familiar I, Nakasujja N, Bangirana P, Opoka R, Giordani B, Boivin M: Immunological correlates of behavioral problems in school-aged children living with HIV in Kayunga, Uganda. Global Mental Health 2015, 2

7. George EC, Walker AS, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Predicting mortality in sick African children: the FEAST Paediatric Emergency Triage (PET) Score. BMC medicine 2015, 13:174.

8. Nyende S, Conroy A, Opoka RO, Namasopo S, Kain KC, Mpimbaza A, Bhargava R, Hawkes M: Solar-powered oxygen delivery: study protocol for a randomized controlled trial. Trials 2015, 16(1):297

9. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Zhong K, Liles WC, John CC, Kain KC: Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013. Emerging infectious diseases 2015, 21(7):1237-1239.

10. Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC: Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness. Critical care (London, England) 2015, 19:47.

11. Hanisch BR, Bangirana P, Opoka RO, Park GS, John CC: Thrombocytopenia May Mediate Disease Severity in Plasmodium falciparum Malaria Through Reduced Transforming Growth Factor Beta-1 Regulation of Proinflammatory and Anti-inflammatory Cytokines. Pediatr Infect Dis J 2015, 34(7):783-788.

12. Familiar I, Ruisenor-Escudero H, Giordani B, Bangirana P, Nakasujja N, Opoka RO, Boivin MJ: Use of BRIEF and CBCL in Ugandan children with HIV or history of severe malaria. J Dev Behav Pediatr 2015, 36(4):277-284.

13. Burkey MD, Murray SM, Bangirana P, Familiar I, Opoka RO, Nakasujja N, Boivin MJ, Bass J: Executive function and attention-deficit/hyperactivity disorder in Ugandan children with perinatal HIV exposure. Global Mental Health 2015, 2:e4.

14. Shabani E, Vercellotti GM, John CC: Reply to Eisenhut. Clin Infect Dis 2015, 60(7):1138-1139.

15. Shabani E, Opoka RO, Idro R, Schmidt R, Park GS, Bangirana P, Vercellotti GM, Hodges JS, Widness JA, John CC: High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria. Clin Infect Dis 2015, 60(1):27-35.

16. Kiguli S, Maitland K, George EC, Olupot-Olupot P, Opoka RO, Engoru C, Akech SO, Nyeko R, Mtove G, Reyburn H et al: Anaemia and blood transfusion in African children presenting to hospital with severe febrile illness. BMC medicine 2015, 13:21.

17. Bangirana P: Cognitive outcome of malaria and HIV infection in children in sub-Saharan Africa. In: Brain Degeneration and Dementia in Sub-Saharan Africa. Edited by Musisi S, Jacobson S. New York: Springer; 2015.

Publications 2014

1. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC: Performance of point-of-care diagnostics for glucose, lactate, and hemoglobin in the management of severe malaria in a resource-constrained hospital in Uganda. Am J Trop Med Hyg 2014, 90(4):605-608.

2. Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC: Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children. Malar J 2014, 13:43.

3. Cusick SE, Opoka RO, Lund TC, John CC, Polgreen LE: Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. PLoS One 2014, 9(12):e113185.

4. Bangirana P, Opoka RO, Boivin MJ, Idro R, Hodges JS, Romero RA, Shapiro E, John CC: Severe malarial anemia is associated with long-term neurocognitive impairment. Clinical Infectious Diseases 2014:doi: 10.1093/cid/ciu1293-doi: 1010.1093/cid/ciu1293.

5. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: Authors’ reply to Southall. BMJ (Clinical research ed) 2014, 348:g1619.

6. Kiguli S, Akech SO, Mtove G, Opoka RO, Engoru C, Olupot-Olupot P, Nyeko R, Evans J, Crawley J, Prevatt N et al: WHO guidelines on fluid resuscitation in children: missing the FEAST data. BMJ (Clinical research ed) 2014, 348:f7003.

Publications 2013

1. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, Bass JK, Opoka RO, Klein PS: A year-long caregiver training program to improve neurocognition in preschool Ugandan HIV-exposed children. J Dev Behav Pediatr 2013, 34(4):269-278.

2. Boivin MJ, Bangirana P, Nakasujja N, Page CF, Shohet C, Givon D, Bass JK, Opoka RO, Klein PS: A year-long caregiver training program improves cognition in preschool Ugandan children with human immunodeficiency virus. The Journal of pediatrics 2013, 163(5):1409-1416 e1401-1405.

3. Bangirana P, Menk J, John CC, Boivin MJ, Hodges JS: The Association between Cognition and Academic Performance in Ugandan Children Surviving Malaria with Neurological Involvement. PLoS ONE 2013, 8(2):e55653-e55653.

4. Bangirana P, Boivin MJ, Giordani B: Computerized Cognitive Rehabilitation Therapy (CCRT) for African Children: Evidence for Neuropsychological Benefit and Future Directions. In: Neuropsychology of Children in Africa. Edited by Boivin MJ, Giordani B: Springer New York; 2013: 277-297.

5. Maitland K, George EC, Evans JA, Kiguli S, Olupot-Olupot P, Akech SO, Opoka RO, Engoru C, Nyeko R, Mtove G et al: Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC medicine 2013,11 :68.

Publications 2012

1. Ruel TD, Boivin MJ, Boal HE, Bangirana P, Charlebois E, Havlir DV, Rosenthal PJ, Dorsey G, Achan J, Akello C et al: Neurocognitive and Motor Deficits in HIV-Infected Ugandan Children With High CD4 Cell Counts. Clin Infect Dis 2012, 54(7):1001-1009.

2. Park GS, Ireland KF, Opoka RO, John CC: Evidence of Endothelial Activation in Asymptomatic Parasitemia and Effect of Blood Group on Levels of von Willebrand Factor in Malaria. Journal of the Pediatric Infectious Diseases Society 2012, 1(1):16-25.

3. Greene JA, Sam-Agudu N, John CC, Opoka RO, Zimmerman PA, Kazura JW: Toll-like receptor polymorphisms and cerebral malaria: TLR2 Delta22 polymorphism is associated with protection from cerebral malaria in a case control study. Malar J 2012, 11:47.

4. Bergemann TL, Bangirana P, Boivin MJ, Connett JE, Giordani BJ, John CC: Statistical Approaches to Assess the Effects of Disease on Neurocognitive Function Over Time. Journal of biometrics & biostatistics 2012, Suppl 7.

Publications 2011

1. Hawkes M, Opoka RO, Namasopo S, Miller C, Thorpe KE, Lavery JV, Conroy AL, Liles WC, John CC, Kain KC: Inhaled nitric oxide for the adjunctive therapy of severe malaria: Protocol for a randomized controlled trial. Trials 2011, 12:176.

2. Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H, Thampi N, Liles WC, John CC et al: Nitric oxide for the adjunctive treatment of severe malaria: Hypothesis and rationale. Med Hypotheses

3. Bangirana P, Musisi S, Boivin MJ, Ehnvall A, John CC, Bergemann TL, Allebeck P: Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviour. Malar J 2011, 10:334.

4. Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, Nyeko R, Mtove G, Reyburn H, Lang T et al: Mortality after fluid bolus in African children with severe infection. The New England journal of medicine 2011, 364(26):2483-2495.

5. Bangirana P, Allebeck P, Boivin MJ, John CC, Page C, Ehnvall A, Musisi S: Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial. BMC Neurology 2011, 11(1):96

Publications 2010

1. Sam-Agudu NA, Greene JA, Opoka RO, Kazura JW, Boivin MJ, Zimmerman PA, Riedesel MA, Bergemann TL, Schimmenti LA, John CC: TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. Am J Trop Med Hyg 2010, 82(4):548-555.

2. Robertson K, Liner J, Hakim J, Sankale J-L, Grant I, Letendre S, Clifford D, Diop AG, Jaye A, Kanmogne G et al: NeuroAIDS in Africa. Journal of Neurovirology 2010, 16(3):189-202.

3. John CC, Kutamba E, Mugarura K, Opoka RO: Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria. Expert Rev Anti Infect Ther 2010, 8(9):997-1008.

4. Boivin MJ, Ruel TD, Boal HE, Bangirana P, Cao H, Eller LA, Charlebois E, Havlir DV, Kamya MR, Achan J et al: HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children. AIDS 2010, 24(8):1163-1170 1110.1097/QAD.1160b1013e3283389dcc

5. Boivin MJ, Busman RA, Parikh SM, Bangirana P, Page CF, Opoka RO, Giordani B: A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV. Neuropsychology 2010, 24(5):667-673.

6. Boivin MJ, Bangirana P, Shaffer RC: The Relationship between Visual-Spatial and Auditory-Verbal Working Memory Span in Senegalese and Ugandan Children. PLoS One 2010, 5(1):e8914.

Publications 2009

1. Lovegrove FE, Tangpukdee N, Opoka RO, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC et al: Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One 2009, 4(3):e4912.

2. Bangirana P, Nakasujja N, Giordani B, Opoka RO, John CC, Boivin MJ: Reliability of the Luganda version of the Child Behaviour Checklist in measuring behavioural problems after cerebral malaria. Child Adolesc Psychiatry Ment Health 2009, 3:38.

3. Bangirana P, Musisi S, Allebeck P, Giordani B, John CC, Opoka RO, Byarugaba J, Ehnvall A, Boivin MJ: A preliminary investigation of the construct validity of the KABC-II in Ugandan children with prior cerebral insult. African Health Sciences 2009, 9(3):186-192.

4. Bangirana P, John CC, Idro R, Opoka RO, Byarugaba J, Jurek AM, Boivin MJ: Socioeconomic predictors of cognition in Ugandan children: implications for community interventions. PLoS One 2009, 4(11):e7898.

5. Bangirana P, Giordani B, John CC, Page C, Opoka RO, Boivin MJ: Immediate Neuropsychological and Behavioral Benefits of Computerized Cognitive Rehabilitation in Ugandan Pediatric Cerebral Malaria Survivors. J Dev Behav Pediatr 2009, 30(4):310-318.

Publications 2008

1. Opoka RO, Xia Z, Bangirana P, John CC: Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria. Pediatr Infect Dis J 2008, 27(4):319-324.

2. John CC, Park GS, Sam-Agudu N, Opoka RO, Boivin MJ: Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease. Cytokine 2008, 41(3):204-208.

3. John CC, Panoskaltsis-Mortari A, Opoka RO, Park GS, Orchard PJ, Jurek AM, Idro R, Byarugaba J, Boivin MJ: Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria. Am J Trop Med Hyg 2008, 78(2):198-205.

4. John CC, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, Wu B, Boivin MJ: Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics 2008, 122(1):e92-99.

Publications 2007

1. Boivin MJ, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, John CC: Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics 2007, 119(2):e360-366.

Publications 2006

1. John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin MJ: Low levels of RANTES are associated with mortality in children with cerebral malaria. J Infect Dis 2006, 194(6):837-845.

2. Bangirana P, Idro R, John CC, Boivin MJ: Rehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitations. Trop Med Int Health 2006, 11(9):1341-1349.