A Multi - Disciplinary Research Collaboration.

INO Jinja

Laboratory assisstant

Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: a Randomized Controlled Trial

 Principal investigator (Uganda):

 Robert Opika Opoka, MB ChB., MMed., MPH. Department of Pediatrics & Child Health, Makerere University College of Health Sciences.

Principal investigator (Canada):

  • Kevin Kain – MD, FRCPC Professor of Medicine, Canada Research Chair in Molecular Parasitology,
  • Director of Global Health – McLaughlin Center for Molecular Medicine, University of Toronto, Director,
  • Sandra A. Rotman Laboratories – McLaughlin-Rotman Centre for Global Health, Director, Center for Travel and Tropical Medicine, Toronto General Hospital


  •  Dr. AbnerTagoola –  MBChB, MMED, MPH, Jinja Regional Referral Hospital
  • Dr. Sophie Namasopo –  MBChB, MMED, Jinja Regional Referral Hospital
  • Dr. Chandy C. John – M.D., M.S., Department of Pediatrics, University of Minnesota.
  • Dr. W. Conrad Liles – MD, PhD, Department of Medicine, University of Toronto
  • Dr. Michael Hawkes – MD, FRCPC, Institute of Medical Sciences, University of Toronto Dr. Christopher Miller, PhD, University of British Columbia

Study site:

 Jinja Regional Referral Hospital, Jinja District.


To determine the efficacy of inhaled nitric oxide for the adjunctive treatment of P. falciparum malaria.

Our specific aim is:

To determine whether supplemental low flow inhaled nitric oxide gas (80 ppm) in addition to Ugandan Standard of Care treatment reduces levels of angiopoeitin-(Ang-2) from baseline in children with moderately severe and severe malaria compared to Standard of Care treatment alone.


Global Health Uganda
Mawanda Road, Plot 667
P.O BOX 33842, Kampala - Uganda
Tel: +256393516707

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