A Multi - Disciplinary Research Collaboration.

Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria


Cerebral malaria (CM) is a severe and often lethal complication of falciparum malaria. A c…

High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda


In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpected…

Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria


Malaria remains a leading cause of childhood death and neurologic disability …

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial


Exposure of red blood cells to oxidants increases production of methemoglobin …

High Postdischarge Morbidity in Ugandan Children With Severe Malarial Anemia or Cerebral Malaria

Opoka RO, Hamre KES, Brand N, Bangirana P, Idro R, John CC: High Postdischarge Morbidity in Ugandan …

Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality

Lactic acidosis (LA) is a marker for mortality in severe malaria, but the mechanisms that l…

Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial.

Severe malaria remains a major cause of global morbidity and mortality. Despite the use of potent an…

Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale.

We hypothesize that supplemental inhaled nitric oxide (iNO) will improve outcomes in children with s…

A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV.


Because antiretroviral treatment (ART) fails to improve neurocognitive impairme…

Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria.

Severe malaria due to Plasmodium falciparum causes more than 800,000 deaths every year. Primary ther…

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