A Multi - Disciplinary Research Collaboration.

Clinical Comparison of Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria


Cerebral malaria (CM) is a severe and often lethal complication of falciparum malaria. A c…

Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial


Exposure of red blood cells to oxidants increases production of methemoglobin …

High Postdischarge Morbidity in Ugandan Children With Severe Malarial Anemia or Cerebral Malaria

Opoka RO, Hamre KES, Brand N, Bangirana P, Idro R, John CC: High Postdischarge Morbidity in Ugandan …

Differing Causes of Lactic Acidosis and Deep Breathing in Cerebral Malaria and Severe Malarial Anemia May Explain Differences in Acidosis-Related Mortality

Lactic acidosis (LA) is a marker for mortality in severe malaria, but the mechanisms that l…

Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial.

Infection with severe malaria in African children is associated with not only a high mortality but a…

Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial.

Severe malaria remains a major cause of global morbidity and mortality. Despite the use of potent an…

Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale.

We hypothesize that supplemental inhaled nitric oxide (iNO) will improve outcomes in children with s…

TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria.

Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infecti…

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